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Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis
BACKGROUND: Antioxidants have a preventive or therapeutic role in oxygen free radical–mediated cell and tissue damage. The study aimed to investigate the therapeutic effects of antioxidants and intranasal steroid fluticasone furoate (FF) on the clinical outcome of patients with perennial allergic rh...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
OceanSide Publications, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010436/ https://www.ncbi.nlm.nih.gov/pubmed/27658183 http://dx.doi.org/10.2500/ar.2016.7.0163 |
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author | Chauhan, Bhushan Gupta, Manish Chauhan, Komal |
author_facet | Chauhan, Bhushan Gupta, Manish Chauhan, Komal |
author_sort | Chauhan, Bhushan |
collection | PubMed |
description | BACKGROUND: Antioxidants have a preventive or therapeutic role in oxygen free radical–mediated cell and tissue damage. The study aimed to investigate the therapeutic effects of antioxidants and intranasal steroid fluticasone furoate (FF) on the clinical outcome of patients with perennial allergic rhinitis. METHODS: Subjects with perennial allergic rhinitis (n = 61) were randomly divided into two groups, group A (n = 30) received FF and group B (n = 31) received FF with antioxidants for 6 weeks. Nasal and ocular symptoms were evaluated weekly by using a four-point categoric scale. The efficacy of the study drug was assessed based on the mean change from baseline of the total daytime nasal symptom scores, total nighttime nasal symptom scores, and the composite symptom scores. RESULTS: The combined therapy (FF with antioxidants) resulted in marked improvements (p ≤ 0.05) in the mean total daytime nasal symptom scores, total nighttime nasal symptom scores, and composite symptom scores of subjects compared with ones treated with intranasal steroid (FF) alone, which highlighted the therapeutic effect of antioxidants in allergic rhinitis. CONCLUSION: Significant improvement in clinical outcome was observed in subjects who received antioxidants along with FF. However, because this was an open-label study, the results must be interpreted with caution, and further double-blind, placebo-controlled, dose-ranging trials supplemented with different antioxidants together with intranasal steroids are suggested. |
format | Online Article Text |
id | pubmed-5010436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | OceanSide Publications, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-50104362016-09-08 Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis Chauhan, Bhushan Gupta, Manish Chauhan, Komal Allergy Rhinol (Providence) Articles BACKGROUND: Antioxidants have a preventive or therapeutic role in oxygen free radical–mediated cell and tissue damage. The study aimed to investigate the therapeutic effects of antioxidants and intranasal steroid fluticasone furoate (FF) on the clinical outcome of patients with perennial allergic rhinitis. METHODS: Subjects with perennial allergic rhinitis (n = 61) were randomly divided into two groups, group A (n = 30) received FF and group B (n = 31) received FF with antioxidants for 6 weeks. Nasal and ocular symptoms were evaluated weekly by using a four-point categoric scale. The efficacy of the study drug was assessed based on the mean change from baseline of the total daytime nasal symptom scores, total nighttime nasal symptom scores, and the composite symptom scores. RESULTS: The combined therapy (FF with antioxidants) resulted in marked improvements (p ≤ 0.05) in the mean total daytime nasal symptom scores, total nighttime nasal symptom scores, and composite symptom scores of subjects compared with ones treated with intranasal steroid (FF) alone, which highlighted the therapeutic effect of antioxidants in allergic rhinitis. CONCLUSION: Significant improvement in clinical outcome was observed in subjects who received antioxidants along with FF. However, because this was an open-label study, the results must be interpreted with caution, and further double-blind, placebo-controlled, dose-ranging trials supplemented with different antioxidants together with intranasal steroids are suggested. OceanSide Publications, Inc. 2016 /pmc/articles/PMC5010436/ /pubmed/27658183 http://dx.doi.org/10.2500/ar.2016.7.0163 Text en Copyright © 2016, OceanSide Publications, Inc., U.S.A. This publication is provided under the terms of the Creative Commons Public License ("CCPL" or "License"), in attribution 3.0 unported (Attribution Non-Commercial No Derivatives (CC BY-NC-ND)), further described at: http://creativecommons.org/licenses/by-nc-nd/3.0/legalcode. The work is protected by copyright and/or other applicable law. Any use of the work other then as authorized under this license or copyright law is prohibited. |
spellingShingle | Articles Chauhan, Bhushan Gupta, Manish Chauhan, Komal Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis |
title | Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis |
title_full | Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis |
title_fullStr | Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis |
title_full_unstemmed | Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis |
title_short | Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis |
title_sort | role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010436/ https://www.ncbi.nlm.nih.gov/pubmed/27658183 http://dx.doi.org/10.2500/ar.2016.7.0163 |
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