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Evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (BIMs)

Difficulties encountered in estimating the biodegradation of poorly water-soluble substances are often linked to their limited bioavailability to microorganisms. Many original bioavailability improvement methods (BIMs) have been described, but no global approach was proposed for a standardized compa...

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Autores principales: Sweetlove, Cyril, Chenèble, Jean-Charles, Barthel, Yves, Boualam, Marc, L’Haridon, Jacques, Thouand, Gérald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010604/
https://www.ncbi.nlm.nih.gov/pubmed/27234835
http://dx.doi.org/10.1007/s11356-016-6899-3
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author Sweetlove, Cyril
Chenèble, Jean-Charles
Barthel, Yves
Boualam, Marc
L’Haridon, Jacques
Thouand, Gérald
author_facet Sweetlove, Cyril
Chenèble, Jean-Charles
Barthel, Yves
Boualam, Marc
L’Haridon, Jacques
Thouand, Gérald
author_sort Sweetlove, Cyril
collection PubMed
description Difficulties encountered in estimating the biodegradation of poorly water-soluble substances are often linked to their limited bioavailability to microorganisms. Many original bioavailability improvement methods (BIMs) have been described, but no global approach was proposed for a standardized comparison of these. The latter would be a valuable tool as part of a wider strategy for evaluating poorly water-soluble substances. The purpose of this study was to define an evaluation strategy following the assessment of different BIMs adapted to poorly water-soluble substances with ready biodegradability tests. The study was performed with two poorly water-soluble chemicals—a solid, anthraquinone, and a liquid, isodecyl neopentanoate—and five BIMs were compared to the direct addition method (reference method), i.e., (i) ultrasonic dispersion, (ii) adsorption onto silica gel, (iii) dispersion using an emulsifier, (iv) dispersion with silicone oil, and (v) dispersion with emulsifier and silicone oil. A two-phase evaluation strategy of solid and liquid chemicals was developed involving the selection of the most relevant BIMs for enhancing the biodegradability of tested substances. A description is given of a BIM classification ratio (R(BIM)), which enables a comparison to be made between the different test chemical sample preparation methods used in the various tests. Thereby, using this comparison, the BIMs giving rise to the greatest biodegradability were ultrasonic dispersion and dispersion with silicone oil or with silicone oil and emulsifier for the tested solid chemical, adsorption onto silica gel, and ultrasonic dispersion for the liquid one. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11356-016-6899-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-50106042016-09-16 Evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (BIMs) Sweetlove, Cyril Chenèble, Jean-Charles Barthel, Yves Boualam, Marc L’Haridon, Jacques Thouand, Gérald Environ Sci Pollut Res Int Research Article Difficulties encountered in estimating the biodegradation of poorly water-soluble substances are often linked to their limited bioavailability to microorganisms. Many original bioavailability improvement methods (BIMs) have been described, but no global approach was proposed for a standardized comparison of these. The latter would be a valuable tool as part of a wider strategy for evaluating poorly water-soluble substances. The purpose of this study was to define an evaluation strategy following the assessment of different BIMs adapted to poorly water-soluble substances with ready biodegradability tests. The study was performed with two poorly water-soluble chemicals—a solid, anthraquinone, and a liquid, isodecyl neopentanoate—and five BIMs were compared to the direct addition method (reference method), i.e., (i) ultrasonic dispersion, (ii) adsorption onto silica gel, (iii) dispersion using an emulsifier, (iv) dispersion with silicone oil, and (v) dispersion with emulsifier and silicone oil. A two-phase evaluation strategy of solid and liquid chemicals was developed involving the selection of the most relevant BIMs for enhancing the biodegradability of tested substances. A description is given of a BIM classification ratio (R(BIM)), which enables a comparison to be made between the different test chemical sample preparation methods used in the various tests. Thereby, using this comparison, the BIMs giving rise to the greatest biodegradability were ultrasonic dispersion and dispersion with silicone oil or with silicone oil and emulsifier for the tested solid chemical, adsorption onto silica gel, and ultrasonic dispersion for the liquid one. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11356-016-6899-3) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2016-05-28 2016 /pmc/articles/PMC5010604/ /pubmed/27234835 http://dx.doi.org/10.1007/s11356-016-6899-3 Text en © The Author(s) 2016 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Article
Sweetlove, Cyril
Chenèble, Jean-Charles
Barthel, Yves
Boualam, Marc
L’Haridon, Jacques
Thouand, Gérald
Evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (BIMs)
title Evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (BIMs)
title_full Evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (BIMs)
title_fullStr Evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (BIMs)
title_full_unstemmed Evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (BIMs)
title_short Evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (BIMs)
title_sort evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (bims)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010604/
https://www.ncbi.nlm.nih.gov/pubmed/27234835
http://dx.doi.org/10.1007/s11356-016-6899-3
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