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Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression

Rare variation in TREM2 has been associated with greater risk for Alzheimer’s disease (AD). TREM2 encodes a cell surface receptor expressed on microglia and related cells, and the R47H variant associated with AD appears to affect the ability of TREM2 to bind extracellular ligands. In addition, other...

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Detalles Bibliográficos
Autores principales:	Sirkis, Daniel W., Bonham, Luke W., Aparicio, Renan E., Geier, Ethan G., Ramos, Eliana Marisa, Wang, Qing, Karydas, Anna, Miller, Zachary A., Miller, Bruce L., Coppola, Giovanni, Yokoyama, Jennifer S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010724/ https://www.ncbi.nlm.nih.gov/pubmed/27589997 http://dx.doi.org/10.1186/s40478-016-0367-7

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