Second-generation inhibitors of Bruton tyrosine kinase

Bruton tyrosine kinase (BTK) is a critical effector molecule for B cell development and plays a major role in lymphoma genesis. Ibrutinib is the first-generation BTK inhibitor. Ibrutinib has off-target effects on EGFR, ITK, and Tec family kinases, which explains the untoward effects of ibrutinib. Re...

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Detalles Bibliográficos
Autores principales: Wu, Jingjing, Liu, Christina, Tsui, Stella T., Liu, Delong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010774/
https://www.ncbi.nlm.nih.gov/pubmed/27590878
http://dx.doi.org/10.1186/s13045-016-0313-y

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