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Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea
PURPOSE: Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. Th...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011050/ https://www.ncbi.nlm.nih.gov/pubmed/27582401 http://dx.doi.org/10.4168/aair.2016.8.6.505 |
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author | Park, Kyung Hee Son, Young Woong Lee, Sang Chul Jeong, Kyunguk Sim, Da Woon Park, Hye Jung Lee, Sooyoung Lee, Jae-Hyun Park, Jung-Won |
author_facet | Park, Kyung Hee Son, Young Woong Lee, Sang Chul Jeong, Kyunguk Sim, Da Woon Park, Hye Jung Lee, Sooyoung Lee, Jae-Hyun Park, Jung-Won |
author_sort | Park, Kyung Hee |
collection | PubMed |
description | PURPOSE: Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy. METHODS: Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled. Peanut-related allergic reactions and sensitization profiles were examined. Specific IgE to Fagales tree pollens (birch, oak), peanut, and their component allergens (Bet v 1, Bet v 2, Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9) were evaluated. Based on these specific IgEs and clinical features, the patients were classified into 4 groups: group 1 (Fagales pollen allergy without OAS), group 2 (Fagales pollen allergy with OAS), group 3 (OAS with peanut anaphylaxis), and group 4 (peanut anaphylaxis). RESULTS: After peanut consumption, one-third of OAS patients experienced oral symptoms not associated with peanut sensitization. Ara h 1 or Ara h 2 was positive in peanut anaphylaxis patients, whereas Ara h 8 was positive in OAS patients. There were 4 patients with both peanut anaphylaxis and OAS (group 3). Both Ara h 2 and Ara h 8 were positive in these patients. Foods associated with OAS in Korea showed unique patterns compared to Westernized countries. CONCLUSIONS: Ara h 2 and Ara h 8 may be important component allergens for discriminating peanut allergy. |
format | Online Article Text |
id | pubmed-5011050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease |
record_format | MEDLINE/PubMed |
spelling | pubmed-50110502016-11-01 Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea Park, Kyung Hee Son, Young Woong Lee, Sang Chul Jeong, Kyunguk Sim, Da Woon Park, Hye Jung Lee, Sooyoung Lee, Jae-Hyun Park, Jung-Won Allergy Asthma Immunol Res Original Article PURPOSE: Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy. METHODS: Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled. Peanut-related allergic reactions and sensitization profiles were examined. Specific IgE to Fagales tree pollens (birch, oak), peanut, and their component allergens (Bet v 1, Bet v 2, Ara h 1, Ara h 2, Ara h 3, Ara h 8, and Ara h 9) were evaluated. Based on these specific IgEs and clinical features, the patients were classified into 4 groups: group 1 (Fagales pollen allergy without OAS), group 2 (Fagales pollen allergy with OAS), group 3 (OAS with peanut anaphylaxis), and group 4 (peanut anaphylaxis). RESULTS: After peanut consumption, one-third of OAS patients experienced oral symptoms not associated with peanut sensitization. Ara h 1 or Ara h 2 was positive in peanut anaphylaxis patients, whereas Ara h 8 was positive in OAS patients. There were 4 patients with both peanut anaphylaxis and OAS (group 3). Both Ara h 2 and Ara h 8 were positive in these patients. Foods associated with OAS in Korea showed unique patterns compared to Westernized countries. CONCLUSIONS: Ara h 2 and Ara h 8 may be important component allergens for discriminating peanut allergy. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2016-11 2016-08-25 /pmc/articles/PMC5011050/ /pubmed/27582401 http://dx.doi.org/10.4168/aair.2016.8.6.505 Text en Copyright © 2016 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Kyung Hee Son, Young Woong Lee, Sang Chul Jeong, Kyunguk Sim, Da Woon Park, Hye Jung Lee, Sooyoung Lee, Jae-Hyun Park, Jung-Won Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea |
title | Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea |
title_full | Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea |
title_fullStr | Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea |
title_full_unstemmed | Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea |
title_short | Clinical Significance of Component Allergens in Fagales Pollen-Sensitized Peanut Allergy in Korea |
title_sort | clinical significance of component allergens in fagales pollen-sensitized peanut allergy in korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011050/ https://www.ncbi.nlm.nih.gov/pubmed/27582401 http://dx.doi.org/10.4168/aair.2016.8.6.505 |
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