Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates

Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates. However, we provide circumstantial evidence for a similar extent of variability. Using...

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Autores principales: Samardzic, Janko, Smits, Anne, Spriet, Isabel, Soldatovic, Ivan, Atkinson, Andrew, Bajcetic, Milica, Van Den Anker, John N., Allegaert, Karel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011197/
https://www.ncbi.nlm.nih.gov/pubmed/27635396
http://dx.doi.org/10.1155/2016/1974972
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author Samardzic, Janko
Smits, Anne
Spriet, Isabel
Soldatovic, Ivan
Atkinson, Andrew
Bajcetic, Milica
Van Den Anker, John N.
Allegaert, Karel
author_facet Samardzic, Janko
Smits, Anne
Spriet, Isabel
Soldatovic, Ivan
Atkinson, Andrew
Bajcetic, Milica
Van Den Anker, John N.
Allegaert, Karel
author_sort Samardzic, Janko
collection PubMed
description Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates. However, we provide circumstantial evidence for a similar extent of variability. Using the same vancomycin dosing regimens and confirming similarity in clinical characteristics, vancomycin trough concentrations measured by PETINIA (2011-2012, n = 400) were 20% lower and the mean difference was 1.93 mg/L compared to COBAS (2012–2014, n = 352) measurements. The impact of vancomycin immunoassays in neonatal matrix was hereby suggested, supporting a switch to more advanced techniques (LC-MS/MS).
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spelling pubmed-50111972016-09-15 Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates Samardzic, Janko Smits, Anne Spriet, Isabel Soldatovic, Ivan Atkinson, Andrew Bajcetic, Milica Van Den Anker, John N. Allegaert, Karel Biomed Res Int Research Article Substantial interassay variability (up to 20%) has been described for vancomycin immunoassays in adults, but the impact of neonatal matrix is difficult to quantify because of blood volume constraints in neonates. However, we provide circumstantial evidence for a similar extent of variability. Using the same vancomycin dosing regimens and confirming similarity in clinical characteristics, vancomycin trough concentrations measured by PETINIA (2011-2012, n = 400) were 20% lower and the mean difference was 1.93 mg/L compared to COBAS (2012–2014, n = 352) measurements. The impact of vancomycin immunoassays in neonatal matrix was hereby suggested, supporting a switch to more advanced techniques (LC-MS/MS). Hindawi Publishing Corporation 2016 2016-08-21 /pmc/articles/PMC5011197/ /pubmed/27635396 http://dx.doi.org/10.1155/2016/1974972 Text en Copyright © 2016 Janko Samardzic et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Samardzic, Janko
Smits, Anne
Spriet, Isabel
Soldatovic, Ivan
Atkinson, Andrew
Bajcetic, Milica
Van Den Anker, John N.
Allegaert, Karel
Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates
title Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates
title_full Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates
title_fullStr Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates
title_full_unstemmed Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates
title_short Different Vancomycin Immunoassays Contribute to the Variability in Vancomycin Trough Measurements in Neonates
title_sort different vancomycin immunoassays contribute to the variability in vancomycin trough measurements in neonates
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011197/
https://www.ncbi.nlm.nih.gov/pubmed/27635396
http://dx.doi.org/10.1155/2016/1974972
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