Advanced Glycation End Products Impair Glucose-Stimulated Insulin Secretion of a Pancreatic β-Cell Line INS-1-3 by Disturbance of Microtubule Cytoskeleton via p38/MAPK Activation

Advanced glycation end products (AGEs) are believed to be involved in diverse complications of diabetes mellitus. Overexposure to AGEs of pancreatic β-cells leads to decreased insulin secretion and cell apoptosis. Here, to understand the cytotoxicity of AGEs to pancreatic β-cells, we used INS-1-3 ce...

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Detalles Bibliográficos
Autores principales: You, Jia, Wang, Zai, Xu, Shiqing, Zhang, Wenjian, Fang, Qing, Liu, Honglin, Peng, Liang, Deng, Tingting, Lou, Jinning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011238/
https://www.ncbi.nlm.nih.gov/pubmed/27635403
http://dx.doi.org/10.1155/2016/9073037

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