Cargando…

Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort

PURPOSE: Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with cardiovascular disease (CVD). A recent study showed that sST2 predicted incident hypertension. High sensitive C-reactive protein (hsCRP) has been a widely-used biomarker for risk-stratifying in CVD. We compared the abil...

Descripción completa

Detalles Bibliográficos
Autores principales: Oh, Jaewon, Park, Sungha, Yu, Hee Tae, Chang, Hyuk-Jae, Lee, Sang-Hak, Kang, Seok-Min, Choi, Donghoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011265/
https://www.ncbi.nlm.nih.gov/pubmed/27593861
http://dx.doi.org/10.3349/ymj.2016.57.6.1347
_version_ 1782451795615809536
author Oh, Jaewon
Park, Sungha
Yu, Hee Tae
Chang, Hyuk-Jae
Lee, Sang-Hak
Kang, Seok-Min
Choi, Donghoon
author_facet Oh, Jaewon
Park, Sungha
Yu, Hee Tae
Chang, Hyuk-Jae
Lee, Sang-Hak
Kang, Seok-Min
Choi, Donghoon
author_sort Oh, Jaewon
collection PubMed
description PURPOSE: Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with cardiovascular disease (CVD). A recent study showed that sST2 predicted incident hypertension. High sensitive C-reactive protein (hsCRP) has been a widely-used biomarker for risk-stratifying in CVD. We compared the abilities of sST2 and hsCRP to predict high risk coronary artery calcium score (CACS). MATERIALS AND METHODS: The CACS was assessed by cardiac computed tomography, and sST2 was measured in 456 subjects enrolled in the Mapo-gu community cohort. In accordance with the 2013 ACC/AHA guidelines, we defined the high risk CACS group as individuals with a CACS ≥300 Agatston units (AU). RESULTS: There were 99 (21.7%) subjects with a CACS ≥300 AU. There was a strong correlation between log sST2 and log hsCRP (r=0.128, p=0.006), and both log sST2 and log hsCRP showed significant associations with CACS (r=0.101, p=0.031 for sST2, r=0.101, p=0.032 for hsCRP). In net reclassification improvement (NRI) analysis, the NRI for hsCRP over sST2 was significant [continuous NRI 0.238, 95% confidence interval (CI) 0.001–0.474, integrated discrimination index (IDI) 0.022, p=0.035], while the NRI for sST2 over hsCRP was not significant (continuous NRI 0.212, 95% CI -0.255–0.453, IDI 0.002, p=0.269). CONCLUSION: sST2 does not improve net reclassification for predicting a high risk CACS. Using hsCRP provides superior discrimination and risk reclassification for coronary atherosclerosis, compared with sST2.
format Online
Article
Text
id pubmed-5011265
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Yonsei University College of Medicine
record_format MEDLINE/PubMed
spelling pubmed-50112652016-11-01 Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort Oh, Jaewon Park, Sungha Yu, Hee Tae Chang, Hyuk-Jae Lee, Sang-Hak Kang, Seok-Min Choi, Donghoon Yonsei Med J Original Article PURPOSE: Soluble ST2 (sST2) is an emerging prognostic biomarker in patients with cardiovascular disease (CVD). A recent study showed that sST2 predicted incident hypertension. High sensitive C-reactive protein (hsCRP) has been a widely-used biomarker for risk-stratifying in CVD. We compared the abilities of sST2 and hsCRP to predict high risk coronary artery calcium score (CACS). MATERIALS AND METHODS: The CACS was assessed by cardiac computed tomography, and sST2 was measured in 456 subjects enrolled in the Mapo-gu community cohort. In accordance with the 2013 ACC/AHA guidelines, we defined the high risk CACS group as individuals with a CACS ≥300 Agatston units (AU). RESULTS: There were 99 (21.7%) subjects with a CACS ≥300 AU. There was a strong correlation between log sST2 and log hsCRP (r=0.128, p=0.006), and both log sST2 and log hsCRP showed significant associations with CACS (r=0.101, p=0.031 for sST2, r=0.101, p=0.032 for hsCRP). In net reclassification improvement (NRI) analysis, the NRI for hsCRP over sST2 was significant [continuous NRI 0.238, 95% confidence interval (CI) 0.001–0.474, integrated discrimination index (IDI) 0.022, p=0.035], while the NRI for sST2 over hsCRP was not significant (continuous NRI 0.212, 95% CI -0.255–0.453, IDI 0.002, p=0.269). CONCLUSION: sST2 does not improve net reclassification for predicting a high risk CACS. Using hsCRP provides superior discrimination and risk reclassification for coronary atherosclerosis, compared with sST2. Yonsei University College of Medicine 2016-11-01 2016-08-30 /pmc/articles/PMC5011265/ /pubmed/27593861 http://dx.doi.org/10.3349/ymj.2016.57.6.1347 Text en © Copyright: Yonsei University College of Medicine 2016 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Oh, Jaewon
Park, Sungha
Yu, Hee Tae
Chang, Hyuk-Jae
Lee, Sang-Hak
Kang, Seok-Min
Choi, Donghoon
Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort
title Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort
title_full Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort
title_fullStr Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort
title_full_unstemmed Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort
title_short Lack of Superiority for Soluble ST2 over High Sensitive C-Reactive Protein in Predicting High Risk Coronary Artery Calcium Score in a Community Cohort
title_sort lack of superiority for soluble st2 over high sensitive c-reactive protein in predicting high risk coronary artery calcium score in a community cohort
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011265/
https://www.ncbi.nlm.nih.gov/pubmed/27593861
http://dx.doi.org/10.3349/ymj.2016.57.6.1347
work_keys_str_mv AT ohjaewon lackofsuperiorityforsolublest2overhighsensitivecreactiveproteininpredictinghighriskcoronaryarterycalciumscoreinacommunitycohort
AT parksungha lackofsuperiorityforsolublest2overhighsensitivecreactiveproteininpredictinghighriskcoronaryarterycalciumscoreinacommunitycohort
AT yuheetae lackofsuperiorityforsolublest2overhighsensitivecreactiveproteininpredictinghighriskcoronaryarterycalciumscoreinacommunitycohort
AT changhyukjae lackofsuperiorityforsolublest2overhighsensitivecreactiveproteininpredictinghighriskcoronaryarterycalciumscoreinacommunitycohort
AT leesanghak lackofsuperiorityforsolublest2overhighsensitivecreactiveproteininpredictinghighriskcoronaryarterycalciumscoreinacommunitycohort
AT kangseokmin lackofsuperiorityforsolublest2overhighsensitivecreactiveproteininpredictinghighriskcoronaryarterycalciumscoreinacommunitycohort
AT choidonghoon lackofsuperiorityforsolublest2overhighsensitivecreactiveproteininpredictinghighriskcoronaryarterycalciumscoreinacommunitycohort