Development of a liquid chromatography high resolution mass spectrometry method for the quantitation of viral envelope glycoprotein in Ebola virus-like particle vaccine preparations

BACKGROUND: Ebola virus like particles (EBOV VLPs, eVLPs), are produced by expressing the viral transmembrane glycoprotein (GP) and structural matrix protein VP40 in mammalian cells. When expressed, these proteins self-assemble and bud from ‘host’ cells displaying morphology similar to infectious vi...

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Detalles Bibliográficos
Autores principales: Cazares, Lisa H., Ward, Michael D., Brueggemann, Ernst E., Kenny, Tara, Demond, Paul, Mahone, Christopher R., Martins, Karen A. O., Nuss, Jonathan E., Glaros, Trevor, Bavari, Sina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011338/
https://www.ncbi.nlm.nih.gov/pubmed/27597813
http://dx.doi.org/10.1186/s12014-016-9119-8

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