Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling

The Structural Classification of Proteins (SCOP) database has facilitated the development of many tools and algorithms and it has been successfully used in protein structure prediction and large-scale genome annotations. During the development of SCOP, numerous exceptions were found to topological r...

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Detalles Bibliográficos
Autor principal: Andreeva, Antonina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011417/
https://www.ncbi.nlm.nih.gov/pubmed/27284063
http://dx.doi.org/10.1042/BST20160053
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author Andreeva, Antonina
author_facet Andreeva, Antonina
author_sort Andreeva, Antonina
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description The Structural Classification of Proteins (SCOP) database has facilitated the development of many tools and algorithms and it has been successfully used in protein structure prediction and large-scale genome annotations. During the development of SCOP, numerous exceptions were found to topological rules, along with complex evolutionary scenarios and peculiarities in proteins including the ability to fold into alternative structures. This article reviews cases of structural variations observed for individual proteins and among groups of homologues, knowledge of which is essential for protein structure modelling.
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spelling pubmed-50114172016-09-05 Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling Andreeva, Antonina Biochem Soc Trans Article The Structural Classification of Proteins (SCOP) database has facilitated the development of many tools and algorithms and it has been successfully used in protein structure prediction and large-scale genome annotations. During the development of SCOP, numerous exceptions were found to topological rules, along with complex evolutionary scenarios and peculiarities in proteins including the ability to fold into alternative structures. This article reviews cases of structural variations observed for individual proteins and among groups of homologues, knowledge of which is essential for protein structure modelling. 2016-06-15 /pmc/articles/PMC5011417/ /pubmed/27284063 http://dx.doi.org/10.1042/BST20160053 Text en https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Andreeva, Antonina
Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling
title Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling
title_full Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling
title_fullStr Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling
title_full_unstemmed Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling
title_short Lessons from making the Structural Classification of Proteins (SCOP) and their implications for protein structure modelling
title_sort lessons from making the structural classification of proteins (scop) and their implications for protein structure modelling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011417/
https://www.ncbi.nlm.nih.gov/pubmed/27284063
http://dx.doi.org/10.1042/BST20160053
work_keys_str_mv AT andreevaantonina lessonsfrommakingthestructuralclassificationofproteinsscopandtheirimplicationsforproteinstructuremodelling

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