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Connexin's Connection in Breast Cancer Growth and Progression
Gap junctions are cell-to-cell junctions that are located in the basolateral surface of two adjoining cells. A gap junction channel is composed of a family of proteins called connexins. Gap junction channels maintain intercellular communication between two cells through the exchange of ions, small m...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011527/ https://www.ncbi.nlm.nih.gov/pubmed/27642298 http://dx.doi.org/10.1155/2016/9025905 |
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author | Banerjee, Debarshi |
author_facet | Banerjee, Debarshi |
author_sort | Banerjee, Debarshi |
collection | PubMed |
description | Gap junctions are cell-to-cell junctions that are located in the basolateral surface of two adjoining cells. A gap junction channel is composed of a family of proteins called connexins. Gap junction channels maintain intercellular communication between two cells through the exchange of ions, small metabolites, and electrical signals. Gap junction channels or connexins are widespread in terms of their expression and function in maintaining the development, differentiation, and homeostasis of vertebrate tissues. Gap junction connexins play a major role in maintaining intercellular communication among different cell types of normal mammary gland for proper development and homeostasis. Connexins have also been implicated in the pathogenesis of breast cancer. Differential expression pattern of connexins and their gap junction dependent or independent functions provide pivotal cross talk of breast tumor cells with the surrounding stromal cell in the microenvironment. Substantial research from the last 20 years has accumulated ample evidences that allow us a better understanding of the roles that connexins play in the tumorigenesis of primary breast tumor and its metastatic progression. This review will summarize the knowledge about the connexins and gap junction activities in breast cancer highlighting the differential expression and functional dynamics of connexins in the pathogenesis of the disease. |
format | Online Article Text |
id | pubmed-5011527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-50115272016-09-18 Connexin's Connection in Breast Cancer Growth and Progression Banerjee, Debarshi Int J Cell Biol Review Article Gap junctions are cell-to-cell junctions that are located in the basolateral surface of two adjoining cells. A gap junction channel is composed of a family of proteins called connexins. Gap junction channels maintain intercellular communication between two cells through the exchange of ions, small metabolites, and electrical signals. Gap junction channels or connexins are widespread in terms of their expression and function in maintaining the development, differentiation, and homeostasis of vertebrate tissues. Gap junction connexins play a major role in maintaining intercellular communication among different cell types of normal mammary gland for proper development and homeostasis. Connexins have also been implicated in the pathogenesis of breast cancer. Differential expression pattern of connexins and their gap junction dependent or independent functions provide pivotal cross talk of breast tumor cells with the surrounding stromal cell in the microenvironment. Substantial research from the last 20 years has accumulated ample evidences that allow us a better understanding of the roles that connexins play in the tumorigenesis of primary breast tumor and its metastatic progression. This review will summarize the knowledge about the connexins and gap junction activities in breast cancer highlighting the differential expression and functional dynamics of connexins in the pathogenesis of the disease. Hindawi Publishing Corporation 2016 2016-08-23 /pmc/articles/PMC5011527/ /pubmed/27642298 http://dx.doi.org/10.1155/2016/9025905 Text en Copyright © 2016 Debarshi Banerjee. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Banerjee, Debarshi Connexin's Connection in Breast Cancer Growth and Progression |
title | Connexin's Connection in Breast Cancer Growth and Progression |
title_full | Connexin's Connection in Breast Cancer Growth and Progression |
title_fullStr | Connexin's Connection in Breast Cancer Growth and Progression |
title_full_unstemmed | Connexin's Connection in Breast Cancer Growth and Progression |
title_short | Connexin's Connection in Breast Cancer Growth and Progression |
title_sort | connexin's connection in breast cancer growth and progression |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011527/ https://www.ncbi.nlm.nih.gov/pubmed/27642298 http://dx.doi.org/10.1155/2016/9025905 |
work_keys_str_mv | AT banerjeedebarshi connexinsconnectioninbreastcancergrowthandprogression |