Cargando…

A novel algorithm for a precise analysis of subchondral bone alterations

Subchondral bone alterations are emerging as considerable clinical problems associated with articular cartilage repair. Their analysis exposes a pattern of variable changes, including intra-lesional osteophytes, residual microfracture holes, peri-hole bone resorption, and subchondral bone cysts. A p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Liang, Orth, Patrick, Goebel, Lars K. H., Cucchiarini, Magali, Madry, Henning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011758/ https://www.ncbi.nlm.nih.gov/pubmed/27596562 http://dx.doi.org/10.1038/srep32982

Ejemplares similares

Subchondral drilling for articular cartilage repair: a systematic review of translational research
por: Gao, Liang, et al.
Publicado: (2018)

Early loss of subchondral bone following microfracture is counteracted by bone marrow aspirate in a translational model of osteochondral repair
por: Gao, Liang, et al.
Publicado: (2017)

Cyst formation in the subchondral bone following cartilage repair
por: Gao, Liang, et al.
Publicado: (2020)

Investigation of microstructural alterations of the human subchondral bone following microfracture penetration reveals effect of three‐dimensional device morphology
por: Onken, Thomas, et al.
Publicado: (2020)

Small-Diameter Subchondral Drilling Improves DNA and Proteoglycan Content of the Cartilaginous Repair Tissue in a Large Animal Model of a Full-Thickness Chondral Defect
por: Orth, Patrick, et al.
Publicado: (2020)

Quantifying the Human Subchondral Trabecular Bone Microstructure in Osteoarthritis with Clinical CT
por: Oláh, Tamás, et al.
Publicado: (2022)

Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects
por: Madry, Henning, et al.
Publicado: (2017)

A high‐resolution cross‐species comparative analysis of the subchondral bone provides insight into critical topographical patterns of the osteochondral unit
por: Michaelis, Jana Christin, et al.
Publicado: (2022)

Gene Therapy for Cartilage Repair
por: Madry, Henning, et al.
Publicado: (2011)

Current perspectives in stem cell research for knee cartilage repair
por: Orth, Patrick, et al.
Publicado: (2014)

Clinical potential and challenges of using genetically modified cells for articular cartilage repair
por: Madry, Henning, et al.
Publicado: (2011)

Association of Nicotine with Osteochondrogenesis and Osteoarthritis Development: The State of the Art of Preclinical Research
por: Cai, Xiaoyu, et al.
Publicado: (2019)

Mitochondrial Genome Editing to Treat Human Osteoarthritis—A Narrative Review
por: Zhong, Gang, et al.
Publicado: (2022)

Application of Alginate Hydrogels for Next-Generation Articular Cartilage Regeneration
por: Liu, Wei, et al.
Publicado: (2022)

Joint Cartilage in Long-Duration Spaceflight
por: Ganse, Bergita, et al.
Publicado: (2022)

The subchondral bone in articular cartilage repair: current problems in the surgical management
por: Gomoll, Andreas H., et al.
Publicado: (2010)

Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno‐Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor‐β Gene Delivery
por: Frisch, Janina, et al.
Publicado: (2016)

Hydrogel-Based Controlled Delivery Systems for Articular Cartilage Repair
por: Rey-Rico, Ana, et al.
Publicado: (2016)

Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis
por: Cucchiarini, Magali, et al.
Publicado: (2014)

Peripheral blood aspirates overexpressing IGF‐I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes
por: Frisch, Janina, et al.
Publicado: (2017)

Biomedical-grade, high mannuronic acid content (BioMVM) alginate enhances the proteoglycan production of primary human meniscal fibrochondrocytes in a 3-D microenvironment
por: Rey-Rico, Ana, et al.
Publicado: (2016)

Reliable landmarks for precise topographical analyses of pathological structural changes of the ovine tibial plateau in 2-D and 3-D subspaces
por: Oláh, Tamás, et al.
Publicado: (2018)

Translational applications of photopolymerizable hydrogels for cartilage repair
por: Meng, Weikun, et al.
Publicado: (2019)

Advances in Human Mitochondria-Based Therapies
por: Zhong, Gang, et al.
Publicado: (2022)

TGF‐β gene transfer and overexpression via rAAV vectors stimulates chondrogenic events in human bone marrow aspirates
por: Frisch, Janina, et al.
Publicado: (2016)

Impact of mechanical stimulation on the chondrogenic processes in human bone marrow aspirates modified to overexpress sox9 via rAAV vectors
por: Venkatesan, Jagadeesh K., et al.
Publicado: (2017)

SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells
por: Venkatesan, Jagadeesh K, et al.
Publicado: (2012)

Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-β and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells
por: Morscheid, Stephanie, et al.
Publicado: (2019)

New trends in articular cartilage repair
por: Cucchiarini, Magali, et al.
Publicado: (2015)

Large animal models in experimental knee sports surgery: focus on clinical translation
por: Madry, Henning, et al.
Publicado: (2015)

Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells
por: Frisch, Janina, et al.
Publicado: (2014)

Knee osteoarthritis patients with more subchondral cysts have altered tibial subchondral bone mineral density
por: Burnett, Wadena D., et al.
Publicado: (2019)

Application of Nanotechnology for Sensitive Detection of Low-Abundance Single-Nucleotide Variations in Genomic DNA: A Review
por: Mukhtar, Mahwash, et al.
Publicado: (2021)

A low morbidity surgical approach to the sheep femoral trochlea
por: Orth, Patrick, et al.
Publicado: (2013)

Is Extracellular Vesicle-Based Therapy the Next Answer for Cartilage Regeneration?
por: Velot, Émilie, et al.
Publicado: (2021)

Effects of rAAV-mediated FGF-2 gene transfer and overexpression upon the chondrogenic differentiation processes in human bone marrow aspirates
por: Frisch, Janina, et al.
Publicado: (2016)

Effects of combined rAAV-mediated TGF-β and sox9 gene transfer and overexpression on the metabolic and chondrogenic activities in human bone marrow aspirates
por: Tao, Ke, et al.
Publicado: (2017)

Subchondral insufficiency fractures, subchondral insufficiency fractures with osteonecrosis, and other apparently spontaneous subchondral bone lesions of the knee—pathogenesis and diagnosis at imaging
por: Malghem, Jacques, et al.
Publicado: (2023)

Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells
por: Tao, Ke, et al.
Publicado: (2016)

Scaffold-Mediated Gene Delivery for Osteochondral Repair
por: Madry, Henning, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_m56roqrp78gvi8d8ctsmotc17e