Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase

BACKGROUND: Tyro3, Axl, and Mertk (TAMs) are a family of three conserved receptor tyrosine kinases that have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigenesis. METHODS: In the present study, we engineered EGFR/TAM chimeric receptors (...

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Detalles Bibliográficos
Autores principales: Kimani, Stanley G., Kumar, Sushil, Davra, Viralkumar, Chang, Yun-Juan, Kasikara, Canan, Geng, Ke, Tsou, Wen-I, Wang, Shenyan, Hoque, Mainul, Boháč, Andrej, Lewis-Antes, Anita, De Lorenzo, Mariana S., Kotenko, Sergei V., Birge, Raymond B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011882/
https://www.ncbi.nlm.nih.gov/pubmed/27595981
http://dx.doi.org/10.1186/s12964-016-0142-1

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