Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy

Tonic GABA(A) receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson’s disease, schizophrenia, and epilepsy...

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Detalles Bibliográficos
Autores principales: Schipper, S., Aalbers, M. W., Rijkers, K., Swijsen, A., Rigo, J. M., Hoogland, G., Vles, J. S. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012145/
https://www.ncbi.nlm.nih.gov/pubmed/26409480
http://dx.doi.org/10.1007/s12035-015-9423-8
Descripción
Sumario:Tonic GABA(A) receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson’s disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABA(A) receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABA(A) receptors in epilepsy and as potential antiepileptic target will be discussed.

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