Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy

Tonic GABA(A) receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson’s disease, schizophrenia, and epilepsy...

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Detalles Bibliográficos
Autores principales: Schipper, S., Aalbers, M. W., Rijkers, K., Swijsen, A., Rigo, J. M., Hoogland, G., Vles, J. S. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012145/
https://www.ncbi.nlm.nih.gov/pubmed/26409480
http://dx.doi.org/10.1007/s12035-015-9423-8
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author Schipper, S.
Aalbers, M. W.
Rijkers, K.
Swijsen, A.
Rigo, J. M.
Hoogland, G.
Vles, J. S. H.
author_facet Schipper, S.
Aalbers, M. W.
Rijkers, K.
Swijsen, A.
Rigo, J. M.
Hoogland, G.
Vles, J. S. H.
author_sort Schipper, S.
collection PubMed
description Tonic GABA(A) receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson’s disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABA(A) receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABA(A) receptors in epilepsy and as potential antiepileptic target will be discussed.
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spelling pubmed-50121452016-09-19 Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy Schipper, S. Aalbers, M. W. Rijkers, K. Swijsen, A. Rigo, J. M. Hoogland, G. Vles, J. S. H. Mol Neurobiol Article Tonic GABA(A) receptors are a subpopulation of receptors that generate long-lasting inhibition and thereby control network excitability. In recent years, these receptors have been implicated in various neurological and psychiatric disorders, including Parkinson’s disease, schizophrenia, and epilepsy. Their distinct subunit composition and function, compared to phasic GABA(A) receptors, opens the possibility to specifically modulate network properties. In this review, the role of tonic GABA(A) receptors in epilepsy and as potential antiepileptic target will be discussed. Springer US 2015-09-26 2016 /pmc/articles/PMC5012145/ /pubmed/26409480 http://dx.doi.org/10.1007/s12035-015-9423-8 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Schipper, S.
Aalbers, M. W.
Rijkers, K.
Swijsen, A.
Rigo, J. M.
Hoogland, G.
Vles, J. S. H.
Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy
title Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy
title_full Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy
title_fullStr Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy
title_full_unstemmed Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy
title_short Tonic GABA(A) Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy
title_sort tonic gaba(a) receptors as potential target for the treatment of temporal lobe epilepsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012145/
https://www.ncbi.nlm.nih.gov/pubmed/26409480
http://dx.doi.org/10.1007/s12035-015-9423-8
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