Cargando…

1.65 Å resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae

ToxT is an AraC-family transcriptional activator protein that controls the expression of key virulence factors in Vibrio cholerae, the causative agent of cholera. ToxT directly activates the expression of the genes that encode the toxin-coregulated pilus and cholera toxin, and also positively auto-r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Jiaqin, Wehmeyer, Graham, Lovell, Scott, Battaile, Kevin P., Egan, Susan M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2016
Materias:	Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012214/ https://www.ncbi.nlm.nih.gov/pubmed/27599865 http://dx.doi.org/10.1107/S2053230X1601298X

Ejemplares similares

A new class of inhibitors of the AraC family virulence regulator Vibrio cholerae ToxT
por: Woodbrey, Anne K., et al.
Publicado: (2017)

The complexity of ToxT-dependent transcription in Vibrio cholerae
por: Weber, Gregor G., et al.
Publicado: (2011)

Small-Molecule Inhibitors of toxT Expression in Vibrio cholerae
por: Anthouard, Rebecca, et al.
Publicado: (2013)

Expression of Cholera Toxin (CT) and the Toxin Co-Regulated Pilus (TCP) by Variants of ToxT in Vibrio cholerae Strains
por: Lee, Donghyun, et al.
Publicado: (2023)

Molecular dynamics simulation (MDS) analysis of Vibrio cholerae ToxT virulence factor complexed with docked potential inhibitors
por: Torktaz, Ibrahim, et al.
Publicado: (2018)

A mannose-sensing AraC-type transcriptional activator regulates cell–cell aggregation of Vibrio cholerae
por: Lee, Hye-Young, et al.
Publicado: (2022)

DNA tape measurements of AraC
por: Rodgers, Michael E., et al.
Publicado: (2008)

Inactivated Vibrio cholerae Strains That Express TcpA via the toxT-139F Allele Induce Antibody Responses against TcpA
por: Kim, Eun Jin, et al.
Publicado: (2022)

AraC-Based Biosensor for the Detection of Isoprene in E. coli
por: Bhat, Shrilaxmi, et al.
Publicado: (2023)

Liposomally trapped AraCTP to overcome AraC resistance in a murine lymphoma in vitro.
por: Richardson, V. J., et al.
Publicado: (1982)

Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis
por: Evangelopoulos, Dimitrios, et al.
Publicado: (2014)

The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU
por: Morgan, Sarah J., et al.
Publicado: (2019)

FoxR is an AraC‐like transcriptional regulator of ferrioxamine uptake in Salmonella enterica
por: Saldaña‐Ahuactzi, Zeus, et al.
Publicado: (2022)

Structural basis of transcription activation by Rob, a pleiotropic AraC/XylS family regulator
por: Shi, Jing, et al.
Publicado: (2022)

Vibrio cholerae’s ToxRS bile sensing system
por: Gubensäk, Nina, et al.
Publicado: (2023)

Prediction of bacterial small RNAs in the RsmA (CsrA) and ToxT pathways: a machine learning approach
por: Fakhry, Carl Tony, et al.
Publicado: (2017)

Disulfide Bond Formation and ToxR Activity in Vibrio cholerae
por: Fengler, Vera H. I., et al.
Publicado: (2012)

Virulence regulator AphB enhances toxR transcription in Vibrio cholerae
por: Xu, Xiao, et al.
Publicado: (2010)

A large family of anti‐activators accompanying XylS/AraC family regulatory proteins
por: Santiago, Araceli E., et al.
Publicado: (2016)

The AraC Negative Regulator family modulates the activity of histone-like proteins in pathogenic bacteria
por: Santiago, Araceli E., et al.
Publicado: (2017)

Signal amplification of araC pBAD using a standardized translation initiation region
por: Shilling, Patrick J, et al.
Publicado: (2022)

Computer-Based Annotation of Putative AraC/XylS-Family Transcription Factors of Known Structure but Unknown Function
por: Schüller, Andreas, et al.
Publicado: (2012)

Low dose docosahexaenoic acid protects normal colonic epithelial cells from araC toxicity
por: Cha, Ming C, et al.
Publicado: (2005)

Blockade of CD82 by a monoclonal antibody potentiates anti-leukemia effects of AraC in vivo
por: Nishioka, Chie, et al.
Publicado: (2015)

Characterization of a novel AraC/XylS-regulated family of N-acyltransferases in pathogens of the order Enterobacterales
por: Belmont-Monroy, Laura, et al.
Publicado: (2020)

AraC interacts with p75(NTR) transmembrane domain to induce cell death of mature neurons
por: Lopes-Rodrigues, Vanessa, et al.
Publicado: (2023)

The AraC-Type Transcriptional Regulator GliR (PA3027) Activates Genes of Glycerolipid Metabolism in Pseudomonas aeruginosa
por: Kotecka, Karolina, et al.
Publicado: (2021)

Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR
por: Gubensäk, Nina, et al.
Publicado: (2021)

ToxR of Vibrio cholerae affects biofilm, rugosity and survival with Acanthamoeba castellanii
por: Valeru, Soni P, et al.
Publicado: (2012)

Diffusible Signal Factors Act through AraC-Type Transcriptional Regulators as Chemical Cues To Repress Virulence of Enteric Pathogens
por: Bosire, Erick Maosa, et al.
Publicado: (2020)

An improved Escherichia coli strain to host gene regulatory networks involving both the AraC and LacI inducible transcription factors
por: Kogenaru, Manjunatha, et al.
Publicado: (2014)

OnfD, an AraC-Type Transcriptional Regulator Encoded by Rhizobium tropici CIAT 899 and Involved in Nod Factor Synthesis and Symbiosis
por: del Cerro, Pablo, et al.
Publicado: (2020)

Unveiling a Virulence-Regulating Mechanism in Aeromonas hydrophila: a Quantitative Exoproteomic Analysis of an AraC-Like Protein
por: Zhang, Lishan, et al.
Publicado: (2023)

Host stimuli and operator binding sites controlling protein interactions between virulence master regulator ToxR and ToxS in Vibrio cholerae
por: Lembke, Mareike, et al.
Publicado: (2020)

4-Chlorophenol Oxidation Depends on the Activation of an AraC-Type Transcriptional Regulator, CphR, in Rhodococcus sp. Strain YH-5B
por: Zhang, Hui, et al.
Publicado: (2018)

Development of a new fluorescent reporter:operator system: location of AraC regulated genes in Escherichia coli K-12
por: Sellars, Laura E., et al.
Publicado: (2017)

Toxin, toxin-coregulated pili, and the toxR regulon are essential for Vibrio cholerae pathogenesis in humans
Publicado: (1988)

Vibrio cholerae ToxR Downregulates Virulence Factor Production in Response to Cyclo(Phe-Pro)
por: Bina, X. Renee, et al.
Publicado: (2013)

Proteolysis of Virulence Regulator ToxR Is Associated with Entry of Vibrio cholerae into a Dormant State
por: Almagro-Moreno, Salvador, et al.
Publicado: (2015)

Proteolysis of ToxR is controlled by cysteine‐thiol redox state and bile salts in Vibrio cholerae
por: Lembke, Mareike, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1shshj3c1mo6hios97k4f0s4f0