Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults

The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis...

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Autores principales: Lasselin, Julie, Kemani, Mike K., Kanstrup, Marie, Olsson, Gunnar L., Axelsson, John, Andreasson, Anna, Lekander, Mats, Wicksell, Rikard K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012257/
https://www.ncbi.nlm.nih.gov/pubmed/27469518
http://dx.doi.org/10.1007/s10865-016-9769-z
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author Lasselin, Julie
Kemani, Mike K.
Kanstrup, Marie
Olsson, Gunnar L.
Axelsson, John
Andreasson, Anna
Lekander, Mats
Wicksell, Rikard K.
author_facet Lasselin, Julie
Kemani, Mike K.
Kanstrup, Marie
Olsson, Gunnar L.
Axelsson, John
Andreasson, Anna
Lekander, Mats
Wicksell, Rikard K.
author_sort Lasselin, Julie
collection PubMed
description The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response.
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spelling pubmed-50122572016-09-19 Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults Lasselin, Julie Kemani, Mike K. Kanstrup, Marie Olsson, Gunnar L. Axelsson, John Andreasson, Anna Lekander, Mats Wicksell, Rikard K. J Behav Med Article The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response. Springer US 2016-07-28 2016 /pmc/articles/PMC5012257/ /pubmed/27469518 http://dx.doi.org/10.1007/s10865-016-9769-z Text en © The Author(s) 2016. This article is published with open access at Springerlink.com 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Lasselin, Julie
Kemani, Mike K.
Kanstrup, Marie
Olsson, Gunnar L.
Axelsson, John
Andreasson, Anna
Lekander, Mats
Wicksell, Rikard K.
Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults
title Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults
title_full Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults
title_fullStr Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults
title_full_unstemmed Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults
title_short Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults
title_sort low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012257/
https://www.ncbi.nlm.nih.gov/pubmed/27469518
http://dx.doi.org/10.1007/s10865-016-9769-z
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