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Diagnosis and implications in the therapeutic management of patient with afebrile neurolepctic malignant syndrome

This report aims at raising clinical awareness for the diagnosis of atypical presentations of neuroleptic malignant syndrome (NMS). We describe the case of a female patient with NMS symptoms, except fever, after starting the use of chlorpromazine. The afebrile condition delayed the consideration of...

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Autores principales: Gomes, Rafael Quintes Ducasble, dos Santos-Júnior, Amilton, Dias, Gabriel Augusto de Araujo Silva, Cais, Carlos Filinto da Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012583/
https://www.ncbi.nlm.nih.gov/pubmed/27606070
http://dx.doi.org/10.1093/omcr/omw067
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author Gomes, Rafael Quintes Ducasble
dos Santos-Júnior, Amilton
Dias, Gabriel Augusto de Araujo Silva
Cais, Carlos Filinto da Silva
author_facet Gomes, Rafael Quintes Ducasble
dos Santos-Júnior, Amilton
Dias, Gabriel Augusto de Araujo Silva
Cais, Carlos Filinto da Silva
author_sort Gomes, Rafael Quintes Ducasble
collection PubMed
description This report aims at raising clinical awareness for the diagnosis of atypical presentations of neuroleptic malignant syndrome (NMS). We describe the case of a female patient with NMS symptoms, except fever, after starting the use of chlorpromazine. The afebrile condition delayed the consideration of NMS by the emergency clinicians who provided her initial assessment. Before this consideration, an anticholinergic agent, not recommended at this condition, was inadvertently prescribed. This might have contributed to the worsening of symptoms. NMS is a life-threatening idiosyncratic reaction most often seen as complication of antipsychotic treatment. Its clinical spectrum is broad and its diagnosis should be considered even if the patients do not fulfill all the possible described symptoms.
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spelling pubmed-50125832016-09-07 Diagnosis and implications in the therapeutic management of patient with afebrile neurolepctic malignant syndrome Gomes, Rafael Quintes Ducasble dos Santos-Júnior, Amilton Dias, Gabriel Augusto de Araujo Silva Cais, Carlos Filinto da Silva Oxf Med Case Reports Case Report This report aims at raising clinical awareness for the diagnosis of atypical presentations of neuroleptic malignant syndrome (NMS). We describe the case of a female patient with NMS symptoms, except fever, after starting the use of chlorpromazine. The afebrile condition delayed the consideration of NMS by the emergency clinicians who provided her initial assessment. Before this consideration, an anticholinergic agent, not recommended at this condition, was inadvertently prescribed. This might have contributed to the worsening of symptoms. NMS is a life-threatening idiosyncratic reaction most often seen as complication of antipsychotic treatment. Its clinical spectrum is broad and its diagnosis should be considered even if the patients do not fulfill all the possible described symptoms. Oxford University Press 2016-09-06 /pmc/articles/PMC5012583/ /pubmed/27606070 http://dx.doi.org/10.1093/omcr/omw067 Text en © The Author 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Gomes, Rafael Quintes Ducasble
dos Santos-Júnior, Amilton
Dias, Gabriel Augusto de Araujo Silva
Cais, Carlos Filinto da Silva
Diagnosis and implications in the therapeutic management of patient with afebrile neurolepctic malignant syndrome
title Diagnosis and implications in the therapeutic management of patient with afebrile neurolepctic malignant syndrome
title_full Diagnosis and implications in the therapeutic management of patient with afebrile neurolepctic malignant syndrome
title_fullStr Diagnosis and implications in the therapeutic management of patient with afebrile neurolepctic malignant syndrome
title_full_unstemmed Diagnosis and implications in the therapeutic management of patient with afebrile neurolepctic malignant syndrome
title_short Diagnosis and implications in the therapeutic management of patient with afebrile neurolepctic malignant syndrome
title_sort diagnosis and implications in the therapeutic management of patient with afebrile neurolepctic malignant syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012583/
https://www.ncbi.nlm.nih.gov/pubmed/27606070
http://dx.doi.org/10.1093/omcr/omw067
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