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Progression of Behavioral and CNS Deficits in a Viable Murine Model of Chronic Neuronopathic Gaucher Disease

To study the neuronal deficits in neuronopathic Gaucher Disease (nGD), the chronological behavioral profiles and the age of onset of brain abnormalities were characterized in a chronic nGD mouse model (9V/null). Progressive accumulation of glucosylceramide (GC) and glucosylsphingosine (GS) in the br...

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Detalles Bibliográficos
Autores principales:	Dai, Mei, Liou, Benjamin, Swope, Brittany, Wang, Xiaohong, Zhang, Wujuan, Inskeep, Venette, Grabowski, Gregory A., Sun, Ying, Pan, Dao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012639/ https://www.ncbi.nlm.nih.gov/pubmed/27598339 http://dx.doi.org/10.1371/journal.pone.0162367

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