SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing

Gain-of-function mutations in the tetrodotoxin (TTX) sensitive voltage-gated sodium channel (Nav) Nav1.7 have been identified as a key mechanism underlying chronic pain in inherited erythromelalgia. Mutations in TTX resistant channels, such as Nav1.8 or Nav1.9, were recently connected with inherited...

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Detalles Bibliográficos
Autores principales: Kist, Andreas M., Sagafos, Dagrun, Rush, Anthony M., Neacsu, Cristian, Eberhardt, Esther, Schmidt, Roland, Lunden, Lars Kristian, Ørstavik, Kristin, Kaluza, Luisa, Meents, Jannis, Zhang, Zhiping, Carr, Thomas Hedley, Salter, Hugh, Malinowsky, David, Wollberg, Patrik, Krupp, Johannes, Kleggetveit, Inge Petter, Schmelz, Martin, Jørum, Ellen, Lampert, Angelika, Namer, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012686/
https://www.ncbi.nlm.nih.gov/pubmed/27598514
http://dx.doi.org/10.1371/journal.pone.0161789

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