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Dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1

Celiac disease (CD) is an autoimmune disease frequently associated with type 1 diabetes (T1D). The prevalence of CD in patients with T1D varies from 3 to 6%. The clinical manifestation of CD in patients with T1D is classified as asymptomatic in about half of cases. Our study aims to determine the fr...

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Autores principales: Bourhanbour, Asmaa Drissi, Ouadghiri, Sanae, Benseffaj, Nadia, Essakalli, Malika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012834/
https://www.ncbi.nlm.nih.gov/pubmed/27642442
http://dx.doi.org/10.11604/pamj.2016.24.103.8555
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author Bourhanbour, Asmaa Drissi
Ouadghiri, Sanae
Benseffaj, Nadia
Essakalli, Malika
author_facet Bourhanbour, Asmaa Drissi
Ouadghiri, Sanae
Benseffaj, Nadia
Essakalli, Malika
author_sort Bourhanbour, Asmaa Drissi
collection PubMed
description Celiac disease (CD) is an autoimmune disease frequently associated with type 1 diabetes (T1D). The prevalence of CD in patients with T1D varies from 3 to 6%. The clinical manifestation of CD in patients with T1D is classified as asymptomatic in about half of cases. Our study aims to determine the frequency of anti-tissue transglutaminase autoantibodies (IgA-tTG) and anti-gliadin antibodies (AGA) in patients with type 1 diabetes in order to early recommend jejunal biopsy and establish a gluten-free diet before the onset of clinical signs and complications of celiac disease. Subjects included in this study were patients with T1D and untreated CD who showed no signs of this disease. The detection of IgG tTG, IgG IgA and IgG AAG was performed using Luminex technology. We enrolled 31 patients. The study involved 16 men and 15 women. IgA AAG were positive in 4(13%) patients and IgG were positive in 7(22,5%) patients. IgA tTG were positive in 3(10%) patients and IgG was positive in one (3%) patient. In our study the association of diabetes type 1 with biomarkers of CD is not uncommon hence the importance of systematic screening for type 1 diabetes. The diagnosis of this atypical and silent CD form is important given the risk of serious complications such as malabsorption and gastrointestinal cancers.
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spelling pubmed-50128342016-09-16 Dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1 Bourhanbour, Asmaa Drissi Ouadghiri, Sanae Benseffaj, Nadia Essakalli, Malika Pan Afr Med J Case Series Celiac disease (CD) is an autoimmune disease frequently associated with type 1 diabetes (T1D). The prevalence of CD in patients with T1D varies from 3 to 6%. The clinical manifestation of CD in patients with T1D is classified as asymptomatic in about half of cases. Our study aims to determine the frequency of anti-tissue transglutaminase autoantibodies (IgA-tTG) and anti-gliadin antibodies (AGA) in patients with type 1 diabetes in order to early recommend jejunal biopsy and establish a gluten-free diet before the onset of clinical signs and complications of celiac disease. Subjects included in this study were patients with T1D and untreated CD who showed no signs of this disease. The detection of IgG tTG, IgG IgA and IgG AAG was performed using Luminex technology. We enrolled 31 patients. The study involved 16 men and 15 women. IgA AAG were positive in 4(13%) patients and IgG were positive in 7(22,5%) patients. IgA tTG were positive in 3(10%) patients and IgG was positive in one (3%) patient. In our study the association of diabetes type 1 with biomarkers of CD is not uncommon hence the importance of systematic screening for type 1 diabetes. The diagnosis of this atypical and silent CD form is important given the risk of serious complications such as malabsorption and gastrointestinal cancers. The African Field Epidemiology Network 2016-05-31 /pmc/articles/PMC5012834/ /pubmed/27642442 http://dx.doi.org/10.11604/pamj.2016.24.103.8555 Text en © Asmaa Drissi Bourhanbour et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Series
Bourhanbour, Asmaa Drissi
Ouadghiri, Sanae
Benseffaj, Nadia
Essakalli, Malika
Dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1
title Dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1
title_full Dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1
title_fullStr Dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1
title_full_unstemmed Dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1
title_short Dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1
title_sort dépistage sérologique de la maladie cœliaque chez des patients marocains atteints de diabète type 1
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012834/
https://www.ncbi.nlm.nih.gov/pubmed/27642442
http://dx.doi.org/10.11604/pamj.2016.24.103.8555
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