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Deletion of African swine fever virus interferon inhibitors from the genome of a virulent isolate reduces virulence in domestic pigs and induces a protective response
African swine fever virus (ASFV) encodes multiple copies of MGF360 and MGF530/505 gene families. These genes have been implicated in the modulation of the type I interferon (IFN) response. We investigated the effect of modulating the IFN response on virus attenuation and induction of protective immu...
Autores principales: | Reis, Ana Luisa, Abrams, Charles C., Goatley, Lynnette C., Netherton, Chris, Chapman, Dave G., Sanchez-Cordon, Pedro, Dixon, Linda K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012891/ https://www.ncbi.nlm.nih.gov/pubmed/27521231 http://dx.doi.org/10.1016/j.vaccine.2016.08.011 |
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