CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPKα2 and enhancing nuclear translocation of Akt1

Cytochrome P450 epoyxgenase 2J2 and epoxyeicosatrienoic acids (EETs) are known to protect against cardiac hypertrophy and heart failure, which involve the activation of 5′‐AMP‐activated protein kinase (AMPK) and Akt. Although the functional roles of AMPK and Akt are well established, the significanc...

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Detalles Bibliográficos
Autores principales: Wang, Bei, Zeng, Hesong, Wen, Zheng, Chen, Chen, Wang, Dao Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013012/
https://www.ncbi.nlm.nih.gov/pubmed/27416746
http://dx.doi.org/10.1111/acel.12507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013012/
https://www.ncbi.nlm.nih.gov/pubmed/27416746
http://dx.doi.org/10.1111/acel.12507

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