Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits

The growth hormone/insulin‐like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF‐related proteins including IGF‐I and IGF‐binding protein‐3 (IGFBP‐3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer....

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Detalles Bibliográficos
Autores principales: Teumer, Alexander, Qi, Qibin, Nethander, Maria, Aschard, Hugues, Bandinelli, Stefania, Beekman, Marian, Berndt, Sonja I., Bidlingmaier, Martin, Broer, Linda, Cappola, Anne, Ceda, Gian Paolo, Chanock, Stephen, Chen, Ming‐Huei, Chen, Tai C., Chen, Yii‐Der Ida, Chung, Jonathan, Del Greco Miglianico, Fabiola, Eriksson, Joel, Ferrucci, Luigi, Friedrich, Nele, Gnewuch, Carsten, Goodarzi, Mark O., Grarup, Niels, Guo, Tingwei, Hammer, Elke, Hayes, Richard B., Hicks, Andrew A., Hofman, Albert, Houwing‐Duistermaat, Jeanine J., Hu, Frank, Hunter, David J., Husemoen, Lise L., Isaacs, Aaron, Jacobs, Kevin B., Janssen, Joop A. M. J. L., Jansson, John‐Olov, Jehmlich, Nico, Johnson, Simon, Juul, Anders, Karlsson, Magnus, Kilpelainen, Tuomas O., Kovacs, Peter, Kraft, Peter, Li, Chao, Linneberg, Allan, Liu, Yongmei, Loos, Ruth J. F., Lorentzon, Mattias, Lu, Yingchang, Maggio, Marcello, Magi, Reedik, Meigs, James, Mellström, Dan, Nauck, Matthias, Newman, Anne B., Pollak, Michael N., Pramstaller, Peter P., Prokopenko, Inga, Psaty, Bruce M., Reincke, Martin, Rimm, Eric B., Rotter, Jerome I., Saint Pierre, Aude, Schurmann, Claudia, Seshadri, Sudha, Sjögren, Klara, Slagboom, P. Eline, Strickler, Howard D., Stumvoll, Michael, Suh, Yousin, Sun, Qi, Zhang, Cuilin, Svensson, Johan, Tanaka, Toshiko, Tare, Archana, Tönjes, Anke, Uh, Hae‐Won, van Duijn, Cornelia M., van Heemst, Diana, Vandenput, Liesbeth, Vasan, Ramachandran S., Völker, Uwe, Willems, Sara M., Ohlsson, Claes, Wallaschofski, Henri, Kaplan, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013013/
https://www.ncbi.nlm.nih.gov/pubmed/27329260
http://dx.doi.org/10.1111/acel.12490

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