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Fragment-Based Whole Cell Screen Delivers Hits against M. tuberculosis and Non-tuberculous Mycobacteria

Reactive multi-target ‘fragment drugs’ represent critical components of current tuberculosis regimens. These compounds, such as pyrazinamide, are old synthetic antimycobacterials that are activated inside Mycobacterium tuberculosis bacilli and are smaller than the usual drug-like, single-target mole...

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Detalles Bibliográficos
Autores principales:	Moreira, Wilfried, Lim, Jia Jie, Yeo, Si Ying, Ramanujulu, Pondy M., Dymock, Brian W., Dick, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013068/ https://www.ncbi.nlm.nih.gov/pubmed/27656168 http://dx.doi.org/10.3389/fmicb.2016.01392

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