Cargando…

ADCOMS: a composite clinical outcome for prodromal Alzheimer's disease trials

BACKGROUND: Development of new therapies for Alzheimer's disease (AD) is increasingly focused on more mildly affected populations, and requires new assessment and outcome strategies. Patients in early stages of AD have mild cognitive decline and no, or limited, functional impairment. To respond...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jinping, Logovinsky, Veronika, Hendrix, Suzanne B, Stanworth, Stephanie H, Perdomo, Carlos, Xu, Lu, Dhadda, Shobha, Do, Ira, Rabe, Martin, Luthman, Johan, Cummings, Jeffrey, Satlin, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Neurodegeneration
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013117/ https://www.ncbi.nlm.nih.gov/pubmed/27010616 http://dx.doi.org/10.1136/jnnp-2015-312383

Ejemplares similares

Prognostic biomarkers in prodromal α-synucleinopathies: DAT binding and REM sleep without atonia
por: Kunz, Dieter, et al.
Publicado: (2023)

Design of a Bayesian adaptive phase 2 proof-of-concept trial for BAN2401, a putative disease-modifying monoclonal antibody for the treatment of Alzheimer's disease
por: Satlin, Andrew, et al.
Publicado: (2016)

GSN gene frameshift mutations in Alzheimer’s disease
por: Jiang, Yaling, et al.
Publicado: (2023)

Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer’s disease
por: Singleton, Ellen, et al.
Publicado: (2021)

CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer’s disease
por: Teuber-Hanselmann, Sarah, et al.
Publicado: (2020)

Plasma biomarkers for Alzheimer’s disease: a field-test in a memory clinic
por: Altomare, Daniele, et al.
Publicado: (2023)

Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer’s disease: systematic review and meta-analysis
por: David, Michael C B, et al.
Publicado: (2022)

Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy
por: Chouliaras, Leonidas, et al.
Publicado: (2022)

Plasma Aβ as a biomarker for predicting Aβ-PET status in Alzheimer’s disease：a systematic review with meta-analysis
por: Cheng, Lizhen, et al.
Publicado: (2022)

Cognitive effects and acceptability of non-invasive brain stimulation on Alzheimer’s disease and mild cognitive impairment: a component network meta-analysis
por: Chu, Che-Sheng, et al.
Publicado: (2021)

Plasma phosphorylated tau 181 predicts amyloid status and conversion to dementia stage dependent on renal function
por: Lehmann, Sylvain, et al.
Publicado: (2023)

Gyrification abnormalities in presymptomatic c9orf72 expansion carriers
por: Caverzasi, Eduardo, et al.
Publicado: (2019)

Primary lateral sclerosis: consensus diagnostic criteria
por: Turner, Martin R, et al.
Publicado: (2020)

Value of systematic genetic screening of patients with amyotrophic lateral sclerosis
por: Shepheard, Stephanie R, et al.
Publicado: (2021)

Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?
por: Kanouchi, Tadashi, et al.
Publicado: (2012)

Medial temporal lobe epilepsy is associated with neuronal fibre loss and paradoxical increase in structural connectivity of limbic structures
por: Bonilha, Leonardo, et al.
Publicado: (2012)

Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans
por: Maccecchini, Maria L, et al.
Publicado: (2012)

An algorithmic approach to structural imaging in dementia
por: Harper, Lorna, et al.
Publicado: (2014)

Validation of the new consensus criteria for the diagnosis of corticobasal degeneration
por: Alexander, S K, et al.
Publicado: (2014)

Cerebrospinal fluid biomarkers in parkinsonian conditions: an update and future directions
por: Magdalinou, Nadia, et al.
Publicado: (2014)

Apolipoprotein E ε2 genotype delays onset of dementia with Lewy bodies in a Norwegian cohort
por: Berge, Guro, et al.
Publicado: (2014)

The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey
por: Turner, Martin R, et al.
Publicado: (2015)

Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study
por: Lu, Ching-Hua, et al.
Publicado: (2015)

Cerebrovascular injury as a risk factor for amyotrophic lateral sclerosis
por: Turner, Martin R, et al.
Publicado: (2016)

Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records
por: Evans, Stephen JW, et al.
Publicado: (2013)

Transcranial magnetic stimulation and amyotrophic lateral sclerosis: pathophysiological insights
por: Vucic, Steve, et al.
Publicado: (2013)

Doxycycline in early CJD: a double-blinded randomised phase II and observational study
por: Varges, Daniela, et al.
Publicado: (2017)

Quantitative EEG parameters correlate with the progression of human prion diseases
por: Franko, Edit, et al.
Publicado: (2016)

Peer support and reminiscence therapy for people with dementia and their family carers: a factorial pragmatic randomised trial
por: Charlesworth, Georgina, et al.
Publicado: (2016)

Neuronal network disintegration: common pathways linking neurodegenerative diseases
por: Ahmed, Rebekah M, et al.
Publicado: (2016)

A clinical tool for predicting survival in ALS
por: Knibb, Jonathan A, et al.
Publicado: (2016)

Widespread structural brain involvement in ALS is not limited to the C9orf72 repeat expansion
por: Westeneng, Henk-Jan, et al.
Publicado: (2016)

Flavour identification in frontotemporal lobar degeneration
por: Omar, Rohani, et al.
Publicado: (2013)

Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis
por: Harper, Lorna, et al.
Publicado: (2017)

Genetic screening in sporadic ALS and FTD
por: Turner, Martin R, et al.
Publicado: (2017)

Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker
por: Kassubek, Jan, et al.
Publicado: (2018)

Laughter, crying and sadness in ALS
por: Thakore, Nimish J, et al.
Publicado: (2017)

Plasma α-synuclein predicts cognitive decline in Parkinson’s disease
por: Lin, Chin-Hsien, et al.
Publicado: (2017)

Imaging and CSF analyses effectively distinguish CJD from its mimics
por: Rudge, Peter, et al.
Publicado: (2018)

Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression
por: Thompson, Andrew Geoffrey Bourne, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_n56kdmod3jhf6678ka0tjug5gp