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Predictors and Modulators of Synthetic Lethality: An Update on PARP Inhibitors and Personalized Medicine

Poly(ADP-ribose) polymerase (PARP) inhibitors have proven to be successful agents in inducing synthetic lethality in several malignancies. Several PARP inhibitors have reached clinical trial testing for treatment in different cancers, and, recently, Olaparib (AZD2281) has gained both United States F...

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Detalles Bibliográficos
Autores principales:	Murata, Stephen, Zhang, Catherine, Finch, Nathan, Zhang, Kevin, Campo, Loredana, Breuer, Eun-Kyoung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013223/ https://www.ncbi.nlm.nih.gov/pubmed/27642590 http://dx.doi.org/10.1155/2016/2346585

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