A Putative Bacterial ABC Transporter Circumvents the Essentiality of Signal Peptidase

The type I signal peptidase of Staphylococcus aureus, SpsB, is an attractive antibacterial target because it is essential for viability and extracellularly accessible. We synthesized compound 103, a novel arylomycin-derived inhibitor of SpsB with significant potency against various clinical S. aureu...

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Detalles Bibliográficos
Autores principales: Morisaki, J. Hiroshi, Smith, Peter A., Date, Shailesh V., Kajihara, Kimberly K., Truong, Chau Linda, Modrusan, Zora, Yan, Donghong, Kang, Jing, Xu, Min, Shah, Ishita M., Mintzer, Robert, Kofoed, Eric M., Cheung, Tommy K., Arnott, David, Koehler, Michael F. T., Heise, Christopher E., Brown, Eric J., Tan, Man-Wah, Hazenbos, Wouter L. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013292/
https://www.ncbi.nlm.nih.gov/pubmed/27601569
http://dx.doi.org/10.1128/mBio.00412-16

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