Cargando…

The efficacy and safety of liraglutide added to metformin in patients with diabetes: a meta-analysis of randomized controlled trials

Liraglutide, a glucagon-like peptide (GLP-1) receptor agonist, has showed favorable effects in the glycaemic control and weight reduction in patients with type 2 diabetes mellitus (T2DM). The meta-analysis was to compare the efficacy and safety of liraglutide added to metformin with other treatments...

Descripción completa

Detalles Bibliográficos
Autores principales: Gu, Jianqiu, Meng, Xin, Guo, Yan, Wang, Lei, Zheng, Hongzhi, Liu, Yixuan, Wu, Bingshu, Wang, Difei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013324/
https://www.ncbi.nlm.nih.gov/pubmed/27600499
http://dx.doi.org/10.1038/srep32714
_version_ 1782452140406472704
author Gu, Jianqiu
Meng, Xin
Guo, Yan
Wang, Lei
Zheng, Hongzhi
Liu, Yixuan
Wu, Bingshu
Wang, Difei
author_facet Gu, Jianqiu
Meng, Xin
Guo, Yan
Wang, Lei
Zheng, Hongzhi
Liu, Yixuan
Wu, Bingshu
Wang, Difei
author_sort Gu, Jianqiu
collection PubMed
description Liraglutide, a glucagon-like peptide (GLP-1) receptor agonist, has showed favorable effects in the glycaemic control and weight reduction in patients with type 2 diabetes mellitus (T2DM). The meta-analysis was to compare the efficacy and safety of liraglutide added to metformin with other treatments in patients with T2DM. A systematic literature search on PubMed, Embase, Web of Science and the Cochrane library databases were performed. Eligible studies were randomized controlled trials (RCTs) of patients with T2DM who received the combination treatment of liraglutide and metformin. Pooled estimates were performed using a fixed-effects model or random-effects model. A total of nine RCTs met the inclusion criteria. Compared with control (placebo, sitagliptin, glimepiride, dulaglutide, insulin glargine, and NPH), liraglutide in combination with metformin resulted in significant reductions in HbA1c, bodyweight, FPG, and PPG, and similar reductions in SBP, and DBP. Moreover, liraglutide combined with metformin did not increase the risk of hypoglycemia, but induced a higher incidence of gastrointestinal disorders. In conclusion, this meta-analysis confirmed the use of liraglutide as add-on to metformin appeared to be effective and safe for patients with T2DM. However, considering the potential limitations in this study, more large-scale, well-conducted RCTs are needed to identify our findings.
format Online
Article
Text
id pubmed-5013324
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-50133242016-09-12 The efficacy and safety of liraglutide added to metformin in patients with diabetes: a meta-analysis of randomized controlled trials Gu, Jianqiu Meng, Xin Guo, Yan Wang, Lei Zheng, Hongzhi Liu, Yixuan Wu, Bingshu Wang, Difei Sci Rep Article Liraglutide, a glucagon-like peptide (GLP-1) receptor agonist, has showed favorable effects in the glycaemic control and weight reduction in patients with type 2 diabetes mellitus (T2DM). The meta-analysis was to compare the efficacy and safety of liraglutide added to metformin with other treatments in patients with T2DM. A systematic literature search on PubMed, Embase, Web of Science and the Cochrane library databases were performed. Eligible studies were randomized controlled trials (RCTs) of patients with T2DM who received the combination treatment of liraglutide and metformin. Pooled estimates were performed using a fixed-effects model or random-effects model. A total of nine RCTs met the inclusion criteria. Compared with control (placebo, sitagliptin, glimepiride, dulaglutide, insulin glargine, and NPH), liraglutide in combination with metformin resulted in significant reductions in HbA1c, bodyweight, FPG, and PPG, and similar reductions in SBP, and DBP. Moreover, liraglutide combined with metformin did not increase the risk of hypoglycemia, but induced a higher incidence of gastrointestinal disorders. In conclusion, this meta-analysis confirmed the use of liraglutide as add-on to metformin appeared to be effective and safe for patients with T2DM. However, considering the potential limitations in this study, more large-scale, well-conducted RCTs are needed to identify our findings. Nature Publishing Group 2016-09-07 /pmc/articles/PMC5013324/ /pubmed/27600499 http://dx.doi.org/10.1038/srep32714 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Gu, Jianqiu
Meng, Xin
Guo, Yan
Wang, Lei
Zheng, Hongzhi
Liu, Yixuan
Wu, Bingshu
Wang, Difei
The efficacy and safety of liraglutide added to metformin in patients with diabetes: a meta-analysis of randomized controlled trials
title The efficacy and safety of liraglutide added to metformin in patients with diabetes: a meta-analysis of randomized controlled trials
title_full The efficacy and safety of liraglutide added to metformin in patients with diabetes: a meta-analysis of randomized controlled trials
title_fullStr The efficacy and safety of liraglutide added to metformin in patients with diabetes: a meta-analysis of randomized controlled trials
title_full_unstemmed The efficacy and safety of liraglutide added to metformin in patients with diabetes: a meta-analysis of randomized controlled trials
title_short The efficacy and safety of liraglutide added to metformin in patients with diabetes: a meta-analysis of randomized controlled trials
title_sort efficacy and safety of liraglutide added to metformin in patients with diabetes: a meta-analysis of randomized controlled trials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013324/
https://www.ncbi.nlm.nih.gov/pubmed/27600499
http://dx.doi.org/10.1038/srep32714
work_keys_str_mv AT gujianqiu theefficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT mengxin theefficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT guoyan theefficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT wanglei theefficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT zhenghongzhi theefficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT liuyixuan theefficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT wubingshu theefficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT wangdifei theefficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT gujianqiu efficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT mengxin efficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT guoyan efficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT wanglei efficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT zhenghongzhi efficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT liuyixuan efficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT wubingshu efficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials
AT wangdifei efficacyandsafetyofliraglutideaddedtometformininpatientswithdiabetesametaanalysisofrandomizedcontrolledtrials