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I too, am America: a review of research on systemic lupus erythematosus in African-Americans

Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder that can cause significant morbidity and mortality. A large body of evidence has shown that African-Americans experience the disease more severely than other racial-ethnic groups. Relevant literature for the years 2000 to August...

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Autores principales: Williams, Edith M, Bruner, Larisa, Adkins, Alyssa, Vrana, Caroline, Logan, Ayaba, Kamen, Diane, Oates, James C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013381/
https://www.ncbi.nlm.nih.gov/pubmed/27651918
http://dx.doi.org/10.1136/lupus-2015-000144
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author Williams, Edith M
Bruner, Larisa
Adkins, Alyssa
Vrana, Caroline
Logan, Ayaba
Kamen, Diane
Oates, James C
author_facet Williams, Edith M
Bruner, Larisa
Adkins, Alyssa
Vrana, Caroline
Logan, Ayaba
Kamen, Diane
Oates, James C
author_sort Williams, Edith M
collection PubMed
description Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder that can cause significant morbidity and mortality. A large body of evidence has shown that African-Americans experience the disease more severely than other racial-ethnic groups. Relevant literature for the years 2000 to August 2015 were obtained from systematic searches of PubMed, Scopus, and the EBSCOHost platform that includes MEDLINE, CINAHL, etc. to evaluate research focused on SLE in African-Americans. Thirty-six of the 1502 articles were classified according to their level of evidence. The systematic review of the literature reported a wide range of adverse outcomes in African-American SLE patients and risk factors observed in other mono and multi-ethnic investigations. Studies limited to African-Americans with SLE identified novel methods for more precise ascertainment of risk and observed novel findings that hadn't been previously reported in African-Americans with SLE. Both environmental and genetic studies included in this review have highlighted unique African-American populations in an attempt to isolate risk attributable to African ancestry and observed increased genetic influence on overall disease in this cohort. The review also revealed emerging research in areas of quality of life, race-tailored interventions, and self-management. This review reemphasizes the importance of additional studies to better elucidate the natural history of SLE in African-Americans and optimize therapeutic strategies for those who are identified as being at high risk.
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spelling pubmed-50133812016-09-20 I too, am America: a review of research on systemic lupus erythematosus in African-Americans Williams, Edith M Bruner, Larisa Adkins, Alyssa Vrana, Caroline Logan, Ayaba Kamen, Diane Oates, James C Lupus Sci Med Review Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder that can cause significant morbidity and mortality. A large body of evidence has shown that African-Americans experience the disease more severely than other racial-ethnic groups. Relevant literature for the years 2000 to August 2015 were obtained from systematic searches of PubMed, Scopus, and the EBSCOHost platform that includes MEDLINE, CINAHL, etc. to evaluate research focused on SLE in African-Americans. Thirty-six of the 1502 articles were classified according to their level of evidence. The systematic review of the literature reported a wide range of adverse outcomes in African-American SLE patients and risk factors observed in other mono and multi-ethnic investigations. Studies limited to African-Americans with SLE identified novel methods for more precise ascertainment of risk and observed novel findings that hadn't been previously reported in African-Americans with SLE. Both environmental and genetic studies included in this review have highlighted unique African-American populations in an attempt to isolate risk attributable to African ancestry and observed increased genetic influence on overall disease in this cohort. The review also revealed emerging research in areas of quality of life, race-tailored interventions, and self-management. This review reemphasizes the importance of additional studies to better elucidate the natural history of SLE in African-Americans and optimize therapeutic strategies for those who are identified as being at high risk. BMJ Publishing Group 2016-08-24 /pmc/articles/PMC5013381/ /pubmed/27651918 http://dx.doi.org/10.1136/lupus-2015-000144 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Review
Williams, Edith M
Bruner, Larisa
Adkins, Alyssa
Vrana, Caroline
Logan, Ayaba
Kamen, Diane
Oates, James C
I too, am America: a review of research on systemic lupus erythematosus in African-Americans
title I too, am America: a review of research on systemic lupus erythematosus in African-Americans
title_full I too, am America: a review of research on systemic lupus erythematosus in African-Americans
title_fullStr I too, am America: a review of research on systemic lupus erythematosus in African-Americans
title_full_unstemmed I too, am America: a review of research on systemic lupus erythematosus in African-Americans
title_short I too, am America: a review of research on systemic lupus erythematosus in African-Americans
title_sort i too, am america: a review of research on systemic lupus erythematosus in african-americans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013381/
https://www.ncbi.nlm.nih.gov/pubmed/27651918
http://dx.doi.org/10.1136/lupus-2015-000144
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