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Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota
Dietary fiber has been shown to prevent high-fat diet induced obesity through modulating the gut microbiota; however, quality difference in fiber type is largely unknown. We performed a 6 week study on C57BL/6J mice fed a macronutrient matched high-fat diet with different fiber types including cellu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013436/ https://www.ncbi.nlm.nih.gov/pubmed/27599699 http://dx.doi.org/10.1038/srep32953 |
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author | Li, Xiufen Guo, Juan Ji, Kailong Zhang, Ping |
author_facet | Li, Xiufen Guo, Juan Ji, Kailong Zhang, Ping |
author_sort | Li, Xiufen |
collection | PubMed |
description | Dietary fiber has been shown to prevent high-fat diet induced obesity through modulating the gut microbiota; however, quality difference in fiber type is largely unknown. We performed a 6 week study on C57BL/6J mice fed a macronutrient matched high-fat diet with different fiber types including cellulose (HFC), bamboo shoot fiber (HFBS) and several other commonly consumed fibers. Our results showed that the HFBS group exhibited the lowest weight gain among all diet groups and had improved lipid profiles and glycemic control compared with the HFC group. As revealed by 16S rRNA gene sequencing, loss of diversity in the gut microbiota induced by the HFC diet was largely prevented by the HFBS diet. Moreover, compared with the HFC diet, the HFBS diet resulted in markedly increased relative abundance of Bacteroidetes and strong inhibition of Verrucomicrobia, two divisions strongly correlated with body weight. In conclusion, the present study provides evidence of a quality difference among different types of dietary fibers and shows that bamboo shoot fiber is the most effective in suppressing high-fat diet induced obesity. Our findings indicate that bamboo shoot fiber is a potential prebiotic fiber which modulates the gut microbiota and improves host metabolism. |
format | Online Article Text |
id | pubmed-5013436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50134362016-09-12 Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota Li, Xiufen Guo, Juan Ji, Kailong Zhang, Ping Sci Rep Article Dietary fiber has been shown to prevent high-fat diet induced obesity through modulating the gut microbiota; however, quality difference in fiber type is largely unknown. We performed a 6 week study on C57BL/6J mice fed a macronutrient matched high-fat diet with different fiber types including cellulose (HFC), bamboo shoot fiber (HFBS) and several other commonly consumed fibers. Our results showed that the HFBS group exhibited the lowest weight gain among all diet groups and had improved lipid profiles and glycemic control compared with the HFC group. As revealed by 16S rRNA gene sequencing, loss of diversity in the gut microbiota induced by the HFC diet was largely prevented by the HFBS diet. Moreover, compared with the HFC diet, the HFBS diet resulted in markedly increased relative abundance of Bacteroidetes and strong inhibition of Verrucomicrobia, two divisions strongly correlated with body weight. In conclusion, the present study provides evidence of a quality difference among different types of dietary fibers and shows that bamboo shoot fiber is the most effective in suppressing high-fat diet induced obesity. Our findings indicate that bamboo shoot fiber is a potential prebiotic fiber which modulates the gut microbiota and improves host metabolism. Nature Publishing Group 2016-09-07 /pmc/articles/PMC5013436/ /pubmed/27599699 http://dx.doi.org/10.1038/srep32953 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Li, Xiufen Guo, Juan Ji, Kailong Zhang, Ping Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota |
title | Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota |
title_full | Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota |
title_fullStr | Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota |
title_full_unstemmed | Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota |
title_short | Bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota |
title_sort | bamboo shoot fiber prevents obesity in mice by modulating the gut microbiota |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013436/ https://www.ncbi.nlm.nih.gov/pubmed/27599699 http://dx.doi.org/10.1038/srep32953 |
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