Cargando…

Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma

Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Xia, Yu, Liu, Li, Bai, Qi, Wang, Jiajun, Xi, Wei, Qu, Yang, Xiong, Ying, Long, Qilai, Xu, Jiejie, Guo, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013447/
https://www.ncbi.nlm.nih.gov/pubmed/27600310
http://dx.doi.org/10.1038/srep32657
_version_ 1782452167122092032
author Xia, Yu
Liu, Li
Bai, Qi
Wang, Jiajun
Xi, Wei
Qu, Yang
Xiong, Ying
Long, Qilai
Xu, Jiejie
Guo, Jianming
author_facet Xia, Yu
Liu, Li
Bai, Qi
Wang, Jiajun
Xi, Wei
Qu, Yang
Xiong, Ying
Long, Qilai
Xu, Jiejie
Guo, Jianming
author_sort Xia, Yu
collection PubMed
description Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 expression in 290 patients with clear cell renal cell carcinoma (ccRCC) through immunohistochemistry on tissue microarrays. We found that dectin-1 was predominantly expressed on ccRCC cells, in accordance with several other online databases. Moreover, Kaplan-Meier method was conducted and high expression of tumoral dectin-1 was associated with shorter patient recurrence free survival (RFS) and overall survival (OS) (P < 0.001 for both). In multivariate analyses, tumoral dectin-1 expression was also confirmed as an independent prognostic factor for patients’ survival together with other clinical parameters (P < 0.001 for RFS and OS). After incorporating these characteristics including tumoral dectin-1 expression, two nomograms were constructed to predict ccRCC patients’ RFS and OS (c-index 0.796 and 0.812, respectively) and performed better than existed integrated models (P < 0.001 for all models comparisons). In conclusion, high tumoral dectin-1 expression was an independent predictor of adverse clinical outcome in ccRCC patients. This molecule and established nomograms might help clinicians in future decision making and therapeutic developments.
format Online
Article
Text
id pubmed-5013447
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-50134472016-09-12 Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma Xia, Yu Liu, Li Bai, Qi Wang, Jiajun Xi, Wei Qu, Yang Xiong, Ying Long, Qilai Xu, Jiejie Guo, Jianming Sci Rep Article Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 expression in 290 patients with clear cell renal cell carcinoma (ccRCC) through immunohistochemistry on tissue microarrays. We found that dectin-1 was predominantly expressed on ccRCC cells, in accordance with several other online databases. Moreover, Kaplan-Meier method was conducted and high expression of tumoral dectin-1 was associated with shorter patient recurrence free survival (RFS) and overall survival (OS) (P < 0.001 for both). In multivariate analyses, tumoral dectin-1 expression was also confirmed as an independent prognostic factor for patients’ survival together with other clinical parameters (P < 0.001 for RFS and OS). After incorporating these characteristics including tumoral dectin-1 expression, two nomograms were constructed to predict ccRCC patients’ RFS and OS (c-index 0.796 and 0.812, respectively) and performed better than existed integrated models (P < 0.001 for all models comparisons). In conclusion, high tumoral dectin-1 expression was an independent predictor of adverse clinical outcome in ccRCC patients. This molecule and established nomograms might help clinicians in future decision making and therapeutic developments. Nature Publishing Group 2016-09-07 /pmc/articles/PMC5013447/ /pubmed/27600310 http://dx.doi.org/10.1038/srep32657 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Xia, Yu
Liu, Li
Bai, Qi
Wang, Jiajun
Xi, Wei
Qu, Yang
Xiong, Ying
Long, Qilai
Xu, Jiejie
Guo, Jianming
Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma
title Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma
title_full Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma
title_fullStr Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma
title_full_unstemmed Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma
title_short Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma
title_sort dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013447/
https://www.ncbi.nlm.nih.gov/pubmed/27600310
http://dx.doi.org/10.1038/srep32657
work_keys_str_mv AT xiayu dectin1predictsadversepostoperativeprognosisofpatientswithclearcellrenalcellcarcinoma
AT liuli dectin1predictsadversepostoperativeprognosisofpatientswithclearcellrenalcellcarcinoma
AT baiqi dectin1predictsadversepostoperativeprognosisofpatientswithclearcellrenalcellcarcinoma
AT wangjiajun dectin1predictsadversepostoperativeprognosisofpatientswithclearcellrenalcellcarcinoma
AT xiwei dectin1predictsadversepostoperativeprognosisofpatientswithclearcellrenalcellcarcinoma
AT quyang dectin1predictsadversepostoperativeprognosisofpatientswithclearcellrenalcellcarcinoma
AT xiongying dectin1predictsadversepostoperativeprognosisofpatientswithclearcellrenalcellcarcinoma
AT longqilai dectin1predictsadversepostoperativeprognosisofpatientswithclearcellrenalcellcarcinoma
AT xujiejie dectin1predictsadversepostoperativeprognosisofpatientswithclearcellrenalcellcarcinoma
AT guojianming dectin1predictsadversepostoperativeprognosisofpatientswithclearcellrenalcellcarcinoma