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Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors

The efficacy of glucosamine (GlcN) and N-acetyl glucosamine (GlcNAc) as agents for chemical exchange saturation transfer (CEST) magnetic resonance molecular imaging of tumors is demonstrated. Both agents reflect the metabolic activity and malignancy of the tumors. The method was tested in two types...

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Autores principales: Rivlin, Michal, Navon, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013519/
https://www.ncbi.nlm.nih.gov/pubmed/27600054
http://dx.doi.org/10.1038/srep32648
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author Rivlin, Michal
Navon, Gil
author_facet Rivlin, Michal
Navon, Gil
author_sort Rivlin, Michal
collection PubMed
description The efficacy of glucosamine (GlcN) and N-acetyl glucosamine (GlcNAc) as agents for chemical exchange saturation transfer (CEST) magnetic resonance molecular imaging of tumors is demonstrated. Both agents reflect the metabolic activity and malignancy of the tumors. The method was tested in two types of tumors implanted orthotopically in mice: 4T(1) (mouse mammary cancer cells) and MCF7 (human mammary cancer cells). 4T(1) is a more aggressive type of tumor than MCF7 and exhibited a larger CEST effect. Two methods of administration of the agents, intravenous (IV) and oral (PO), gave similar results. The CEST MRI observation of lung metastasis was confirmed by histology. The potential of the clinical application of CEST MRI with these agents for cancer diagnosis is strengthened by their lack of toxicity as can be indicated from their wide use as food supplements.
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spelling pubmed-50135192016-09-12 Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors Rivlin, Michal Navon, Gil Sci Rep Article The efficacy of glucosamine (GlcN) and N-acetyl glucosamine (GlcNAc) as agents for chemical exchange saturation transfer (CEST) magnetic resonance molecular imaging of tumors is demonstrated. Both agents reflect the metabolic activity and malignancy of the tumors. The method was tested in two types of tumors implanted orthotopically in mice: 4T(1) (mouse mammary cancer cells) and MCF7 (human mammary cancer cells). 4T(1) is a more aggressive type of tumor than MCF7 and exhibited a larger CEST effect. Two methods of administration of the agents, intravenous (IV) and oral (PO), gave similar results. The CEST MRI observation of lung metastasis was confirmed by histology. The potential of the clinical application of CEST MRI with these agents for cancer diagnosis is strengthened by their lack of toxicity as can be indicated from their wide use as food supplements. Nature Publishing Group 2016-09-07 /pmc/articles/PMC5013519/ /pubmed/27600054 http://dx.doi.org/10.1038/srep32648 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Rivlin, Michal
Navon, Gil
Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors
title Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors
title_full Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors
title_fullStr Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors
title_full_unstemmed Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors
title_short Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors
title_sort glucosamine and n-acetyl glucosamine as new cest mri agents for molecular imaging of tumors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013519/
https://www.ncbi.nlm.nih.gov/pubmed/27600054
http://dx.doi.org/10.1038/srep32648
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