Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts

A convenient and environmentally friendly protocol for the preparation of biaryls at room temperature under continuous flow conditions is reported. A simple reductive homo-coupling Ullmann-type reaction was performed in an H-Cube mini using commercially available supported Pd catalysts under mild re...

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Autores principales: Feiz, Afsaneh, Bazgir, Ayoob, Balu, Alina M., Luque, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013534/
https://www.ncbi.nlm.nih.gov/pubmed/27600989
http://dx.doi.org/10.1038/srep32719
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author Feiz, Afsaneh
Bazgir, Ayoob
Balu, Alina M.
Luque, Rafael
author_facet Feiz, Afsaneh
Bazgir, Ayoob
Balu, Alina M.
Luque, Rafael
author_sort Feiz, Afsaneh
collection PubMed
description A convenient and environmentally friendly protocol for the preparation of biaryls at room temperature under continuous flow conditions is reported. A simple reductive homo-coupling Ullmann-type reaction was performed in an H-Cube mini using commercially available supported Pd catalysts under mild reaction conditions, with quantitative conversion to target products. Commercial Pd catalysts were found to be highly stable under the investigated reaction conditions, with a minimum Pd leaching into solution after several reaction runs (ca. 20 h on stream).
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spelling pubmed-50135342016-09-12 Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts Feiz, Afsaneh Bazgir, Ayoob Balu, Alina M. Luque, Rafael Sci Rep Article A convenient and environmentally friendly protocol for the preparation of biaryls at room temperature under continuous flow conditions is reported. A simple reductive homo-coupling Ullmann-type reaction was performed in an H-Cube mini using commercially available supported Pd catalysts under mild reaction conditions, with quantitative conversion to target products. Commercial Pd catalysts were found to be highly stable under the investigated reaction conditions, with a minimum Pd leaching into solution after several reaction runs (ca. 20 h on stream). Nature Publishing Group 2016-09-07 /pmc/articles/PMC5013534/ /pubmed/27600989 http://dx.doi.org/10.1038/srep32719 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Feiz, Afsaneh
Bazgir, Ayoob
Balu, Alina M.
Luque, Rafael
Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts
title Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts
title_full Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts
title_fullStr Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts
title_full_unstemmed Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts
title_short Continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported Pd catalysts
title_sort continuous flow room temperature reductive aqueous homo-coupling of aryl halides using supported pd catalysts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013534/
https://www.ncbi.nlm.nih.gov/pubmed/27600989
http://dx.doi.org/10.1038/srep32719
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