A substrate-driven allosteric switch that enhances PDI catalytic activity

Protein disulfide isomerase (PDI) is an oxidoreductase essential for folding proteins in the endoplasmic reticulum. The domain structure of PDI is a–b–b′–x–a′, wherein the thioredoxin-like a and a′ domains mediate disulfide bond shuffling and b and b′ domains are substrate binding. The b′ and a′ dom...

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Detalles Bibliográficos
Autores principales: Bekendam, Roelof H., Bendapudi, Pavan K., Lin, Lin, Nag, Partha P., Pu, Jun, Kennedy, Daniel R., Feldenzer, Alexandra, Chiu, Joyce, Cook, Kristina M., Furie, Bruce, Huang, Mingdong, Hogg, Philip J., Flaumenhaft, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013553/
https://www.ncbi.nlm.nih.gov/pubmed/27573496
http://dx.doi.org/10.1038/ncomms12579

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