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Neutrophil recruitment limited by high-affinity bent β(2) integrin binding ligand in cis
Neutrophils are essential for innate immunity and inflammation and many neutrophil functions are β(2) integrin-dependent. Integrins can extend (E(+)) and acquire a high-affinity conformation with an ‘open' headpiece (H(+)). The canonical switchblade model of integrin activation proposes that th...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013657/ https://www.ncbi.nlm.nih.gov/pubmed/27578049 http://dx.doi.org/10.1038/ncomms12658 |