Cargando…
Prediction and validation of protein intermediate states from structurally rich ensembles and coarse-grained simulations
Protein conformational changes are at the heart of cell functions, from signalling to ion transport. However, the transient nature of the intermediates along transition pathways hampers their experimental detection, making the underlying mechanisms elusive. Here we retrieve dynamic information on th...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013691/ https://www.ncbi.nlm.nih.gov/pubmed/27578633 http://dx.doi.org/10.1038/ncomms12575 |