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Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse
The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Japan (JSTP), Europe (ESTP), Great Britain (BSTP) and North America (STP) to develop an internationally-accepted...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Society of Toxicologic Pathology
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013710/ https://www.ncbi.nlm.nih.gov/pubmed/27621537 http://dx.doi.org/10.1293/tox.29.3S-1 |
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author | Berridge, Brian R. Mowat, Vasanthi Nagai, Hirofumi Nyska, Abraham Okazaki, Yoshimasa Clements, Peter J. Rinke, Matthias Snyder, Paul W. Boyle, Michael C. Wells, Monique Y. |
author_facet | Berridge, Brian R. Mowat, Vasanthi Nagai, Hirofumi Nyska, Abraham Okazaki, Yoshimasa Clements, Peter J. Rinke, Matthias Snyder, Paul W. Boyle, Michael C. Wells, Monique Y. |
author_sort | Berridge, Brian R. |
collection | PubMed |
description | The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Japan (JSTP), Europe (ESTP), Great Britain (BSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The primary purpose of this publication is to provide a standardized nomenclature for characterizing lesions observed in the cardiovascular (CV) system of rats and mice commonly used in drug or chemical safety assessment. The standardized nomenclature presented in this document is also available electronically for society members on the internet (http://goreni.org). Accurate and precise morphologic descriptions of changes in the CV system are important for understanding the mechanisms and pathogenesis of those changes, differentiation of natural and induced injuries and their ultimate functional consequence. Challenges in nomenclature are associated with lesions or pathologic processes that may present as a temporal or pathogenic spectrum or when natural and induced injuries share indistinguishable features. Specific nomenclature recommendations are offered to provide a consistent approach. |
format | Online Article Text |
id | pubmed-5013710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Japanese Society of Toxicologic Pathology |
record_format | MEDLINE/PubMed |
spelling | pubmed-50137102016-09-12 Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse Berridge, Brian R. Mowat, Vasanthi Nagai, Hirofumi Nyska, Abraham Okazaki, Yoshimasa Clements, Peter J. Rinke, Matthias Snyder, Paul W. Boyle, Michael C. Wells, Monique Y. J Toxicol Pathol Review The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Japan (JSTP), Europe (ESTP), Great Britain (BSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The primary purpose of this publication is to provide a standardized nomenclature for characterizing lesions observed in the cardiovascular (CV) system of rats and mice commonly used in drug or chemical safety assessment. The standardized nomenclature presented in this document is also available electronically for society members on the internet (http://goreni.org). Accurate and precise morphologic descriptions of changes in the CV system are important for understanding the mechanisms and pathogenesis of those changes, differentiation of natural and induced injuries and their ultimate functional consequence. Challenges in nomenclature are associated with lesions or pathologic processes that may present as a temporal or pathogenic spectrum or when natural and induced injuries share indistinguishable features. Specific nomenclature recommendations are offered to provide a consistent approach. Japanese Society of Toxicologic Pathology 2016-07-29 2016 /pmc/articles/PMC5013710/ /pubmed/27621537 http://dx.doi.org/10.1293/tox.29.3S-1 Text en ©2016 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Review Berridge, Brian R. Mowat, Vasanthi Nagai, Hirofumi Nyska, Abraham Okazaki, Yoshimasa Clements, Peter J. Rinke, Matthias Snyder, Paul W. Boyle, Michael C. Wells, Monique Y. Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse |
title | Non-proliferative and Proliferative Lesions of the Cardiovascular System of
the Rat and Mouse |
title_full | Non-proliferative and Proliferative Lesions of the Cardiovascular System of
the Rat and Mouse |
title_fullStr | Non-proliferative and Proliferative Lesions of the Cardiovascular System of
the Rat and Mouse |
title_full_unstemmed | Non-proliferative and Proliferative Lesions of the Cardiovascular System of
the Rat and Mouse |
title_short | Non-proliferative and Proliferative Lesions of the Cardiovascular System of
the Rat and Mouse |
title_sort | non-proliferative and proliferative lesions of the cardiovascular system of
the rat and mouse |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013710/ https://www.ncbi.nlm.nih.gov/pubmed/27621537 http://dx.doi.org/10.1293/tox.29.3S-1 |
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