A multicenter phase I study of preoperative chemoradiotherapy with S-1 and irinotecan for locally advanced lower rectal cancer (SAMRAI-1)

BACKGROUND AND PURPOSE: Preoperative 5-fluorouracil-based chemoradiotherapy is a standard treatment for locally advanced lower rectal cancer (LALRC). We performed a phase I study to develop a new regimen combining irinotecan and S-1. MATERIALS AND METHODS: Patients with LALRC (T3-4, N0-2) were studi...

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Detalles Bibliográficos
Autores principales: Sato, Takeo, Hayakawa, Kazushige, Tomita, Naohiro, Noda, Masafumi, Kamikonya, Norihiko, Watanabe, Toshiaki, Kato, Daiki, Sakai, Yoshiharu, Hiraoka, Masahiro, Shimada, Mitsuo, Ikushima, Hitoshi, Baba, Hideo, Oya, Natsuo, Oya, Masatoshi, Nemoto-Murofushi, Keiko, Takeuchi, Masahiro, Watanabe, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Scientific Publishers 2016
Materias:
Phase I trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013752/
https://www.ncbi.nlm.nih.gov/pubmed/27317556
http://dx.doi.org/10.1016/j.radonc.2016.06.002

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