Downregulation of miR-219 enhances brain-derived neurotrophic factor production in mouse dorsal root ganglia to mediate morphine analgesic tolerance by upregulating CaMKIIγ

BACKGROUND: Increasing evidence suggests that microRNAs are functionally involved in the initiation and maintenance of pain hypersensitivity, including chronic morphine analgesic tolerance, through the posttranscriptional regulation of pain-related genes. We have previously demonstrated that miR-219...

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Detalles Bibliográficos
Autores principales: Hu, Xue-Ming, Cao, Shou-Bin, Zhang, Hai-Long, Lyu, Dong-Mei, Chen, Li-Ping, Xu, Heng, Pan, Zhi-Qiang, Shen, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014090/
https://www.ncbi.nlm.nih.gov/pubmed/27599867
http://dx.doi.org/10.1177/1744806916666283

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