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Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice

SHANK3 (also called PROSAP2) genetic haploinsufficiency is thought to be the major cause of neuropsychiatric symptoms in Phelan-McDermid syndrome (PMS). PMS is a rare genetic disorder that causes a severe form of intellectual disability (ID), expressive language delays and other autistic features. F...

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Detalles Bibliográficos
Autores principales:	Vicidomini, Cinzia, Ponzoni, Luisa, Lim, Dmitry, Schmeisser, Michael, Reim, Dominik, Morello, Noemi, Orelanna, Daniel, Tozzi, Alessandro, Durante, Valentina, Scalmani, Paolo, Mantegazza, Massimo, Genazzani, Armando A., Giustetto, Maurizio, Sala, Mariaelvina, Calabresi, Paolo, Boeckers, Tobias M., Sala, Carlo, Verpelli, Chiara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014121/ https://www.ncbi.nlm.nih.gov/pubmed/27021819 http://dx.doi.org/10.1038/mp.2016.30

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