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Rationale for Quality Assurance in Fecal Egg Monitoring of Soil-Transmitted Helminthiasis

Substantial investment has been made into the once “neglected” tropical disease, soil-transmitted helminthiasis, and into control programs that operate within a framework of mapping baseline disease distribution, measuring the effectiveness of applied interventions, establishing when to cease drug a...

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Detalles Bibliográficos
Autores principales: Hoekendijk, David J. L., Hill, Philip C., Sowerby, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014248/
https://www.ncbi.nlm.nih.gov/pubmed/27352875
http://dx.doi.org/10.4269/ajtmh.15-0463
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author Hoekendijk, David J. L.
Hill, Philip C.
Sowerby, Stephen J.
author_facet Hoekendijk, David J. L.
Hill, Philip C.
Sowerby, Stephen J.
author_sort Hoekendijk, David J. L.
collection PubMed
description Substantial investment has been made into the once “neglected” tropical disease, soil-transmitted helminthiasis, and into control programs that operate within a framework of mapping baseline disease distribution, measuring the effectiveness of applied interventions, establishing when to cease drug administration, and for posttreatment evaluations. However, critical to each of these stages is the determination of helminth infection. The limitations of traditional microscope-based fecal egg diagnostics have not provided quality assurance in the monitoring of parasite disease and suboptimal treatment regimes provide for the potential development of parasite resistance to anthelmintic drugs. Improved diagnostic and surveillance tools are required to protect therapeutic effectiveness and to maintain funder confidence. Such tools may be on the horizon with emergent technologies that offer potential for enhanced visualization and quality-assured quantitation of helminth eggs.
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spelling pubmed-50142482016-09-14 Rationale for Quality Assurance in Fecal Egg Monitoring of Soil-Transmitted Helminthiasis Hoekendijk, David J. L. Hill, Philip C. Sowerby, Stephen J. Am J Trop Med Hyg Perspective Pieces Substantial investment has been made into the once “neglected” tropical disease, soil-transmitted helminthiasis, and into control programs that operate within a framework of mapping baseline disease distribution, measuring the effectiveness of applied interventions, establishing when to cease drug administration, and for posttreatment evaluations. However, critical to each of these stages is the determination of helminth infection. The limitations of traditional microscope-based fecal egg diagnostics have not provided quality assurance in the monitoring of parasite disease and suboptimal treatment regimes provide for the potential development of parasite resistance to anthelmintic drugs. Improved diagnostic and surveillance tools are required to protect therapeutic effectiveness and to maintain funder confidence. Such tools may be on the horizon with emergent technologies that offer potential for enhanced visualization and quality-assured quantitation of helminth eggs. The American Society of Tropical Medicine and Hygiene 2016-09-07 /pmc/articles/PMC5014248/ /pubmed/27352875 http://dx.doi.org/10.4269/ajtmh.15-0463 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Perspective Pieces
Hoekendijk, David J. L.
Hill, Philip C.
Sowerby, Stephen J.
Rationale for Quality Assurance in Fecal Egg Monitoring of Soil-Transmitted Helminthiasis
title Rationale for Quality Assurance in Fecal Egg Monitoring of Soil-Transmitted Helminthiasis
title_full Rationale for Quality Assurance in Fecal Egg Monitoring of Soil-Transmitted Helminthiasis
title_fullStr Rationale for Quality Assurance in Fecal Egg Monitoring of Soil-Transmitted Helminthiasis
title_full_unstemmed Rationale for Quality Assurance in Fecal Egg Monitoring of Soil-Transmitted Helminthiasis
title_short Rationale for Quality Assurance in Fecal Egg Monitoring of Soil-Transmitted Helminthiasis
title_sort rationale for quality assurance in fecal egg monitoring of soil-transmitted helminthiasis
topic Perspective Pieces
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014248/
https://www.ncbi.nlm.nih.gov/pubmed/27352875
http://dx.doi.org/10.4269/ajtmh.15-0463
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