Single Nucleotide Polymorphisms at +191 and +292 of Galectin-3 Gene (LGALS3) Related to Lower GAL-3 Serum Levels Are Associated with Frequent Respiratory Tract Infection and Vaso-Occlusive Crisis in Children with Sickle Cell Anemia

INTRODUCTION: Patients with sickle cell anemia (SCA) may present chronic hemolytic anemia, vaso-occlusion and respiratory tract infection (RTI) episodes. Galectin-3 (GAL-3) is a multifunctional protein involved in inflammation, apoptosis, adhesion and resistance to reactive oxygen species. Studies p...

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Detalles Bibliográficos
Autores principales: de Mendonça Belmont, Taciana Furtado, do Ó, Kleyton Palmeira, Soares da Silva, Andreia, de Melo Vilar, Kamila, Silva Medeiros, Fernanda, Silva Vasconcelos, Luydson Richardson, Mendonça dos Anjos, Ana Claudia, Domingues Hatzlhofer, Betânia Lucena, Pitta, Maíra Galdino da Rocha, Bezerra, Marcos André Cavalcanti, Araújo, Aderson da Silva, de Melo Rego, Moacyr Jesus Barreto, Moura, Patrícia, Cavalcanti, Maria do Socorro Mendonça
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014331/
https://www.ncbi.nlm.nih.gov/pubmed/27603703
http://dx.doi.org/10.1371/journal.pone.0162297

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