A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy

Epidermolytic palmoplantar keratoderma (EPPK) is a relatively common autosomal-dominant skin disorder caused by mutations in the keratin 9 gene (KRT9), with few therapeutic options for the affected so far. Here, we report a knock-in transgenic mouse model that carried a small insertion–deletion (ind...

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Detalles Bibliográficos
Autores principales: Lyu, Ya-Su, Shi, Pei-liang, Chen, Xiao-Ling, Tang, Yue-Xiao, Wang, Yan-Fang, Liu, Rong-Rong, Luan, Xiao-Rui, Fang, Yu, Mei, Ru-Huan, Du, Zhen-Fang, Ke, Hai-Ping, Matro, Erik, Li, Ling-En, Lin, Zhao-Yu, Zhao, Jing, Gao, Xiang, Zhang, Xian-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014458/
https://www.ncbi.nlm.nih.gov/pubmed/27003758
http://dx.doi.org/10.1038/mtna.2016.17

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