Reprogramming of Pancreatic Exocrine Cells AR42J Into Insulin-producing Cells Using mRNAs for Pdx1, Ngn3, and MafA Transcription Factors

Direct reprogramming of pancreatic nonendocrine cells into insulin-producing β-cells represents a promising approach for the treatment of insulin-dependent diabetes. However, its clinical application is limited by the potential for insertional mutagenesis associated with the viral vectors currently...

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Detalles Bibliográficos
Autores principales: Koblas, Tomas, Leontovyc, Ivan, Loukotova, Sarka, Kosinova, Lucie, Saudek, Frantisek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014516/
https://www.ncbi.nlm.nih.gov/pubmed/27187823
http://dx.doi.org/10.1038/mtna.2016.33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014516/
https://www.ncbi.nlm.nih.gov/pubmed/27187823
http://dx.doi.org/10.1038/mtna.2016.33

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