Augmented endothelial exocytosis of angiopoietin-2 resulting from CCM3-deficiency contributes to the progression of cerebral cavernous malformation

Cerebral cavernous malformations (CCMs) are vascular malformations that affect the central nervous system and result in cerebral hemorrhage, seizure and stroke. CCM arises from loss-of-function mutations in one of three genes: CCM1, CCM2 and CCM3 (PDCD10). CCM3 mutations in human often result in a m...

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Detalles Bibliográficos
Autores principales: Jenny Zhou, Huanjiao, Qin, Lingfeng, Zhang, Haifeng, Tang, Wenwen, Ji, Weidong, He, Yun, Liang, Xiaoling, Wang, Zongren, Yuan, Qianying, Vortmeyer, Alexander, Toomre, Derek, Fuh, Germaine, Yan, Minghong, Kluger, Martin S., Wu, Dianqing, Min, Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014607/
https://www.ncbi.nlm.nih.gov/pubmed/27548575
http://dx.doi.org/10.1038/nm.4169

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