Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma

The protein kinase V-Raf murine sarcoma viral oncogene homolog B (BRAF) is an oncogenic driver and therapeutic target in melanoma. Inhibitors of BRAF (BRAFi) have shown high response rates and extended survival in melanoma patients bearing tumors that express BRAF Val600 mutations, but a vast majori...

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Detalles Bibliográficos
Autores principales: Shen, Che-Hung, Kim, Sun Hye, Trousil, Sebastian, Frederick, Dennie T., Piris, Adriano, Yuan, Ping, Cai, Li, Gu, Lei, Li, Man, Lee, Jung Hyun, Mitra, Devarati, Fisher, David E., Sullivan, Ryan J., Flaherty, Keith T., Zheng, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014622/
https://www.ncbi.nlm.nih.gov/pubmed/27500726
http://dx.doi.org/10.1038/nm.4155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014622/
https://www.ncbi.nlm.nih.gov/pubmed/27500726
http://dx.doi.org/10.1038/nm.4155

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