Deciphering the role of DNA methylation in multiple sclerosis: emerging issues

Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system that involves several not yet fully elucidated pathophysiologic mechanisms. There is increasing evidence that epigenetic modifications at level of DNA bases, histones, and micro-RNAs may...

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Autores principales: Sokratous, Maria, Dardiotis, Efthimios, Tsouris, Zisis, Bellou, Eleni, Michalopoulou, Amalia, Siokas, Vasileios, Arseniou, Stylianos, Stamati, Tzeni, Tsivgoulis, Georgios, Bogdanos, Dimitrios, Hadjigeorgiou, Georgios M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014764/
https://www.ncbi.nlm.nih.gov/pubmed/27605361
http://dx.doi.org/10.1007/s13317-016-0084-z
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author Sokratous, Maria
Dardiotis, Efthimios
Tsouris, Zisis
Bellou, Eleni
Michalopoulou, Amalia
Siokas, Vasileios
Arseniou, Stylianos
Stamati, Tzeni
Tsivgoulis, Georgios
Bogdanos, Dimitrios
Hadjigeorgiou, Georgios M.
author_facet Sokratous, Maria
Dardiotis, Efthimios
Tsouris, Zisis
Bellou, Eleni
Michalopoulou, Amalia
Siokas, Vasileios
Arseniou, Stylianos
Stamati, Tzeni
Tsivgoulis, Georgios
Bogdanos, Dimitrios
Hadjigeorgiou, Georgios M.
author_sort Sokratous, Maria
collection PubMed
description Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system that involves several not yet fully elucidated pathophysiologic mechanisms. There is increasing evidence that epigenetic modifications at level of DNA bases, histones, and micro-RNAs may confer risk for MS. DNA methylation seems to have a prominent role in the epigenetics of MS, as aberrant methylation in the promoter regions across genome may underlie several processes involved in the initiation and development of MS. In the present review, we discuss current understanding regarding the role of DNA methylation in MS, possible therapeutic implications and future emerging issues.
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spelling pubmed-50147642016-09-08 Deciphering the role of DNA methylation in multiple sclerosis: emerging issues Sokratous, Maria Dardiotis, Efthimios Tsouris, Zisis Bellou, Eleni Michalopoulou, Amalia Siokas, Vasileios Arseniou, Stylianos Stamati, Tzeni Tsivgoulis, Georgios Bogdanos, Dimitrios Hadjigeorgiou, Georgios M. Auto Immun Highlights Review Article Multiple sclerosis (MS) is an autoimmune inflammatory and neurodegenerative disease of the central nervous system that involves several not yet fully elucidated pathophysiologic mechanisms. There is increasing evidence that epigenetic modifications at level of DNA bases, histones, and micro-RNAs may confer risk for MS. DNA methylation seems to have a prominent role in the epigenetics of MS, as aberrant methylation in the promoter regions across genome may underlie several processes involved in the initiation and development of MS. In the present review, we discuss current understanding regarding the role of DNA methylation in MS, possible therapeutic implications and future emerging issues. Springer International Publishing 2016-09-07 /pmc/articles/PMC5014764/ /pubmed/27605361 http://dx.doi.org/10.1007/s13317-016-0084-z Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Sokratous, Maria
Dardiotis, Efthimios
Tsouris, Zisis
Bellou, Eleni
Michalopoulou, Amalia
Siokas, Vasileios
Arseniou, Stylianos
Stamati, Tzeni
Tsivgoulis, Georgios
Bogdanos, Dimitrios
Hadjigeorgiou, Georgios M.
Deciphering the role of DNA methylation in multiple sclerosis: emerging issues
title Deciphering the role of DNA methylation in multiple sclerosis: emerging issues
title_full Deciphering the role of DNA methylation in multiple sclerosis: emerging issues
title_fullStr Deciphering the role of DNA methylation in multiple sclerosis: emerging issues
title_full_unstemmed Deciphering the role of DNA methylation in multiple sclerosis: emerging issues
title_short Deciphering the role of DNA methylation in multiple sclerosis: emerging issues
title_sort deciphering the role of dna methylation in multiple sclerosis: emerging issues
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014764/
https://www.ncbi.nlm.nih.gov/pubmed/27605361
http://dx.doi.org/10.1007/s13317-016-0084-z
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