Cargando…

A Tetraspecific VHH-Based Neutralizing Antibody Modifies Disease Outcome in Three Animal Models of Clostridium difficile Infection

Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia. The incidence of community-acquired infection has increas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmidt, Diane J., Beamer, Gillian, Tremblay, Jacqueline M., Steele, Jennifer A., Kim, Hyeun Bum, Wang, Yaunkai, Debatis, Michele, Sun, Xingmin, Kashentseva, Elena A., Dmitriev, Igor P., Curiel, David T., Shoemaker, Charles B., Tzipori, Saul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Clinical Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014919/ https://www.ncbi.nlm.nih.gov/pubmed/27413067 http://dx.doi.org/10.1128/CVI.00730-15

Ejemplares similares

Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein
por: Mukherjee, Jean, et al.
Publicado: (2014)

A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters
por: Wang, Yuan-Kai, et al.
Publicado: (2015)

Systemically Administered IgG Anti-Toxin Antibodies Protect the Colonic Mucosa during Infection with Clostridium difficile in the Piglet Model
por: Cohen, Ocean R., et al.
Publicado: (2014)

Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
por: Yang, Guilin, et al.
Publicado: (2008)

Neutralizing epitopes on Clostridioides difficile toxin A revealed by the structures of two camelid VHH antibodies
por: Chen, Baohua, et al.
Publicado: (2022)

The Enterotoxicity of Clostridium difficile Toxins
por: Sun, Xingmin, et al.
Publicado: (2010)

Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function
por: Tremblay, Jacqueline M., et al.
Publicado: (2020)

Two VHH Antibodies Neutralize Botulinum Neurotoxin E1 by Blocking Its Membrane Translocation in Host Cells
por: Lam, Kwok-Ho, et al.
Publicado: (2020)

Enteric pharmacokinetics of monomeric and multimeric camelid nanobody single-domain antibodies
por: Debatis, Michelle, et al.
Publicado: (2023)

Use of VHH antibodies for the development of antigen detection test for visceral leishmaniasis
por: Abeijon, Claudia, et al.
Publicado: (2018)

Novel Chimeric Protein Vaccines Against Clostridium difficile Infection
por: Wang, Shaohui, et al.
Publicado: (2018)

Lactobacillli expressing llama VHH fragments neutralise Lactococcus phages
por: Hultberg, Anna, et al.
Publicado: (2007)

Inhibition of HIV Virus by Neutralizing Vhh Attached to Dual Functional Liposomes Encapsulating Dapivirine
por: Wang, Scarlet Xiaoyan, et al.
Publicado: (2016)

Evaluation of the Xpert Clostridium difficile Assay for the Diagnosis of Clostridium difficile Infection
por: Shin, Saeam, et al.
Publicado: (2012)

Antibiotic Resistance and Toxin Production of Clostridium difficile Isolates from the Hospitalized Patients in a Large Hospital in Florida
por: Peng, Zhong, et al.
Publicado: (2017)

Etymologia: Clostridium difficile
Publicado: (2010)

Clostridium: Transmission difficile?
por: Harbarth, Stephan, et al.
Publicado: (2012)

Clostridium difficile Infection
por: Feuerstadt, Paul
Publicado: (2015)

Clostridium difficile infection
por: Geller, Stephen A., et al.
Publicado: (2014)

Clostridium difficile Infection
por: Magdesian, K. Gary
Publicado: (2003)

Efficient Genome Editing Achieved via Plug-and-Play Adenovirus Piggyback Transport of Cas9/gRNA Complex on Viral Capsid Surface
por: Lu, Zhi Hong, et al.
Publicado: (2022)

Immunogenicity and protective efficacy of recombinant Clostridium difficile flagellar protein FliC
por: Ghose, Chandrabali, et al.
Publicado: (2016)

GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery
por: van Schie, Loes, et al.
Publicado: (2023)

The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis
por: Lee, Sangun, et al.
Publicado: (2017)

Susceptibility of Hamsters to Clostridium difficile Isolates of Differing Toxinotype
por: Buckley, Anthony M., et al.
Publicado: (2013)

Etiology of Infectious Diarrhea in Patients Tested for Clostridium difficile: If It Isn’t Clostridium difficile, What Is It?
por: Kwon, Jennie H, et al.
Publicado: (2017)

Tetraspecific scFv construct provides NK cell mediated ADCC and self-sustaining stimuli via insertion of IL-15 as a cross-linker
por: Schmohl, Joerg U., et al.
Publicado: (2016)

Search for Resonant and Non-Resonant VHH Production
por: Kyriacou, Nicholas Graves
Publicado: (2022)

Clostridium difficile infections in China()
por: Jin, Ke, et al.
Publicado: (2010)

The structure of the S-layer of Clostridium difficile
por: Bradshaw, William J., et al.
Publicado: (2017)

Clostridium difficile infection: review
por: Czepiel, Jacek, et al.
Publicado: (2019)

Clostridium difficile Causing Empyema
por: Mohamed, Abdalla, et al.
Publicado: (2018)

Controversies in Clostridium difficile testing
por: Fedorko, Daniel P.
Publicado: (2002)

Combinatorial strategies based on CRAd-IL24 and CRAd-ING4 virotherapy with anti-angiogenesis treatment for ovarian cancer
por: Ashshi, Ahmad Mohammad, et al.
Publicado: (2016)

Targeting Clostridium difficile Surface Components to Develop Immunotherapeutic Strategies Against Clostridium difficile Infection
por: Péchiné, Séverine, et al.
Publicado: (2018)

Accuracy of Xpert Clostridium difficile assay for the diagnosis of Clostridium difficile infection: A meta analysis
por: Bai, Yuanyuan, et al.
Publicado: (2017)

Clostridium difficile infection: Is there a change in the underlying factors? Inflammatory bowel disease and Clostridium difficile
por: Bolukcu, Sibel, et al.
Publicado: (2019)

Construction of a camelid VHH yeast two-hybrid library and the selection of VHH against haemagglutinin-neuraminidase protein of the Newcastle disease virus
por: Gao, Xiaolong, et al.
Publicado: (2016)

A New Gorilla Adenoviral Vector with Natural Lung Tropism Avoids Liver Toxicity and Is Amenable to Capsid Engineering and Vector Retargeting
por: Lu, Zhi Hong, et al.
Publicado: (2020)

Comparison of Supplemented Brucella Agar and Modified Clostridium difficile Agar for Antimicrobial Susceptibility Testing of Clostridium difficile
por: Kim, Gye Hyeong, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jem36oj2v1gub4g4npfgu19n90