Therapeutic TNF Inhibitors can Differentially Stabilize Trimeric TNF by Inhibiting Monomer Exchange

Tumor necrosis factor (TNF) is a homotrimeric cytokine that is a key mediator of inflammation. It is unstable at physiological concentrations and slowly converts into an inactive form. Here, we investigated the mechanism of this process by using a Förster resonance energy transfer (FRET) assay that...

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Detalles Bibliográficos
Autores principales: van Schie, Karin A., Ooijevaar-de Heer, Pleuni, Dijk, Lisanne, Kruithof, Simone, Wolbink, Gertjan, Rispens, Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015024/
https://www.ncbi.nlm.nih.gov/pubmed/27605058
http://dx.doi.org/10.1038/srep32747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015024/
https://www.ncbi.nlm.nih.gov/pubmed/27605058
http://dx.doi.org/10.1038/srep32747

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